Publications by authors named "Viviana Maria Gianguzzo"
The discovery of serine protease proprotein convertase subtilisin-kexin type 9 (PCSK9) has revolutionized pharmacological lipid-lowering treatments. The first PCSK9 antagonists (PCSK9-A), evolocumab and alirocumab, were approved in 2015. Targeting PCSK9 synthesis marked a major advancement in this field, leading to the development of inclisiran, a long-acting siRNA targeting PCSK9 mRNA.
View Article and Find Full Text PDFAtrial fibrillation (AF) prevalence increases in older patients which also show a high thromboembolic risk. Oral anticoagulants (OACs) are recommended to prevent cardioembolic events and direct oral anticoagulants (DOACs) improved anti-thrombotic treatment. However, the benefits/risks of anticoagulant in older patients still need to be completely defined.
View Article and Find Full Text PDFEffects of a Dietary Supplement Composed of Baicalin, Bromelain and Escin for Venous Chronic Insufficiency Treatment: Insights from a Retrospective Observational Study.
Pharmaceuticals (Basel)
June 2024
Article Synopsis
- Chronic venous insufficiency (CVI) can increase the risk of cardiovascular events, and its primary treatments are compression stockings and lifestyle changes, potentially supported by natural products like flavonoids.
- This study evaluated the effects of a dietary supplement containing baicalin, bromelain, and escin in CVI patients through a retrospective analysis of medical records.
- Results showed significant improvements in the clinical symptoms of "users" of the supplement compared to "non-users," including reduced pain, inflammation, and overall severity of CVI, along with lower C-reactive Protein levels.
Article Synopsis
- The study aimed to analyze changes in glomerular filtration ratio (GFR) among diabetic patients and identify related risk factors under the care of General Practitioners (GPs).
- Researchers recruited 545 diabetic patients, estimated their GFR based on creatinine values, and used linear regression to determine predictors of eGFR changes.
- Findings revealed that most patients were on glucose-lowering medications, often had prescriptions for nephrotoxic drugs, and highlighted the need for closer monitoring of diabetic patients' kidney health, irrespective of their current GFR levels.