Publications by authors named "Vivian O N Teixeira"
Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) are currently used to treat mutant cancers. Although PARPi sensitivity has been attributed to homologous recombination (HR) defects, other roles of HR factors have also been linked to response to PARPi, including replication fork protection. In this study, we investigated PARPi sensitivity in ovarian cancer patient-derived xenograft (PDX) models in relation to HR proficiency and replication fork protection.
View Article and Find Full Text PDFAims: The heterozygous phospholamban (PLN) mutation R14del (PLN R14del ) is associated with a severe arrhythmogenic cardiomyopathy (ACM) developing in the adult. "Superinhibition" of SERCA2a by PLN R14del is widely assumed to underlie the pathogenesis, but alternative mechanisms such abnormal energy metabolism have also been reported. This work aims to (1) to evaluate Ca dynamics and energy metabolism in a transgenic (TG) mouse model of the mutation prior to cardiomyopathy development; (2) to test whether they are causally connected.
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- Rheumatoid arthritis is a disease that affects the muscles and can make it hard to move; this study looked at how two treatments help with this in mice.
- Mice with arthritis were given either etanercept or methotrexate, and researchers found that etanercept did a better job at keeping muscle weight normal.
- Results showed that etanercept kept muscle proteins at healthy levels, while methotrexate didn't help as much, and both treatments slowed the disease down.
There is no consensus for diagnosis or treatment of RA muscle loss. We aimed to investigate metabolites in arthritic mice urine as biomarkers of muscle loss. DBA1/J mice comprised collagen-induced arthritis (CIA) and control (CO) groups.
View Article and Find Full Text PDFThe available chemotherapeutic drugs for the treatment of leishmaniasis present problems relating to efficacy, emergence of parasite resistance, and adverse effects and cost. Azole antifungal drugs have been repurposed for this proposition but the clinical response has been variable. In this sense, this study assessed the leishmanicidal and immunomodulatory activities of azoles-derived imidazolium salts (IS), being the ionic imidazole-derived equivalents: 1-n-butyl-3-methylimidazolium chloride (CMImCl), 1-n-decyl-3-methylimidazolium chloride (CMImCl), 1-n-hexadecyl-3-methylimidazolium chloride (CMImCl), 1-n-hexadecyl-3-methylimidazolium methanesulfonate (CMImMeS), 1-n-hexadecyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (CMImNTf) and 1-methyl-3-n-octadecylimidazolium chloride (CMImCl).
View Article and Find Full Text PDFCollagen-induced arthritis as an animal model of rheumatoid cachexia.
J Cachexia Sarcopenia Muscle
June 2018
Background: Rheumatoid arthritis is characterized by chronic polyarticular synovitis and presents systemic changes that impact quality of life, such as impaired muscle function, seen in up to 66% of the patients. This can progress to severely debilitating state known as rheumatoid cachexia-without loss of fat mass and body weight-for which there is little consensus in terms of diagnosis or treatment. This study aims to evaluate whether the collagen-induced arthritis (CIA) animal model also develops clinical and functional features characteristic of rheumatoid cachexia.
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- Rheumatoid arthritis (RA) is a disease that harms the joints, and certain cells called fibroblast-like synoviocytes (FLS) are important in how it works.
- Researchers studied how a special protein called gastrin-releasing peptide (GRP) and its receptor (GRPR) affect the behavior of FLS in mice, especially how they grow and spread.
- They found that GRP makes FLS more invasive, but if a blocker for GRPR is used, it stops this effect. This research might help develop new treatments for RA by understanding how GRP and GRPR work together.