Prostate-specific Antigen at 3 Months as a Predictor of Radiologic Progression-free Survival in Metastatic Hormone-sensitive Prostate Cancer Treated with Apalutamide: Analysis of 633 Patients in a Real-world Database.

Background And Objective: The depth of the prostate-specific antigen (PSA) decline after androgen receptor pathway inhibitor (ARPI) treatment combined with androgen deprivation therapy for patients with metastatic hormone-sensitive prostate cancer (mHSPC) may affect prognosis. The primary objective in our study was the correlation between the PSA response at 3 mo and radiologic progression-free survival (rPFS) at 24 mo. Three groups were defined according to the PSA decline: complete response (PSA ≤0.

Targeted prophylactic anticoagulation based on the TRiP(cast) score in patients with lower limb immobilisation: a multicentre, stepped wedge, randomised implementation trial.

Background: Prophylactic anticoagulation in emergency department patients with lower limb trauma requiring immobilisation is controversial. The Thrombosis Risk Prediction for Patients with Cast Immobilisation-TRiP(cast)-score could identify a large subgroup of patients at low risk of venous thromboembolism for whom prophylactic anticoagulation can be safely withheld. We aimed to prospectively assess the safety of withholding anticoagulation for patients with lower limb trauma at low risk of venous thromboembolism, defined by a TRiP(cast) score of less than 7.

Nephrectomy in 52 dogs for the treatment of Dioctophyme renale infection - Knowing the enemy to win.

Dioctophyme renale (D. renale) is a nematode that parasitizes the kidney of mammals. Treatment is often surgical, with removal of the affected organ.

Two auricular epithesis surgical cases retained by a custom titanium implant: result at four years.

Introduction: This article aims at describing the four-year outcome of a surgical procedure implanting a patient specific epithesis system in two patients.

Technical Note: After virtual 3D reconstruction of the anatomy and mirroring of the healthy ear, the position of the three Locator attachments were optimized in the software to embed them as accurately as possible in the planned episthesis antihelix. The personalized plate bearing the three Locator implants was then manufactured.

Factors influencing cardiometabolic risk profile in patients with psoriasis.

Background: Psoriasis has been associated with metabolic syndrome and with an increased cardiovascular risk especially in patients with severe disease. The goal of this study was to estimate the prevalence of metabolic syndrome and other cardiovascular risk factors and its association with the psoriasis severity, sex and age.

Methods: Consecutive patients with psoriasis were enrolled in a prospective study over a 1-year period.

Disease progression of dermatophytic pseudomycetoma in a Persian cat.

Background: Dermatophytic pseudomycetoma is a subcutaneous fungal infection by Microsporum canis.

Aims: This work describes a case of dermatophytic pseudomycetoma in a Persian cat.

Patient And Methods: A 3-year old female Persian cat showing alopecia, scaling and ulcerated nodules throughout the body, with presence of ulcerated nodules with yellow granular discharges on the dorsum, close to the tail.

Functional morphology of unguiculiform papillae of the reticular groove in the ruminant stomach.

The arrangement of the ruminant stomach in four gastric compartments with specialized mucosal papillae along the gastric groove (GG) has been previously described. However, a debate remains about functional implications of these morphological pecularities. This study was aimed to elucidate the relation between the papillar morphology and its putative functions.

[Asian tiger mosquito bites: perception of the affected population after Aedes albopictus became established in Spain].

Introduction: The presence of Aedes albopictus was detected in Spain in 2004 and it has now become fully established, causing significant discomfort among the population in the affected areas.

Objectives: The aim of this study was to investigate the impact of the arrival of A albopictus and its subsequent establishment on the population a year after being detected in Spain.

Material And Methods: A survey questioned 309 users of the Valldoreix-Sant Cugat Healthcare Center about their knowledge of Aedes albopictus, the characteristics of bites by this insect, and their attitude to prevention and treatment.

[Congenital dermatofibrosarcoma protuberans: a case report].

Dermatofibrosarcoma protuberans is a rare low-grade fibrohistiocytic tumor with onset normally at ages between 20 and 50 years. It presents as a violaceous plaque or macule with an appearance suggestive of vascular lesion, on which nodular lesions appear later. Histological diagnosis is based on the presence of a spindle-cell tumor arranged in small bundles in a characteristic cartwheel pattern.

Atrophic dermatofibroma accompanied by aneurysmatic characteristics.

A 40-year-old man presented a painful haemorrhagic plaque on his chest in the same location where a nodular lesion had been presented for many years. After 2 months, the plaque was replaced by a depressed lesion. The lesion diagnosed as an anetoderma was excised and the biopsy showed an atrophic dermatofibroma accompanied by aneurysmatic characteristics.

[Study of immutable variables determining rHuEPO dose requirements on hemodialysis patients].

Patients receiving recombinant human erythropoietin (rHuEPO) therapy show wide variability in their responsiveness to the drug. Variables that affect rHuEPO dose requirements can be broadly divided into modificable and immutable characteristics. Most of the scientific research on rHuEPO hyporesponsiveness has focused on modificable variables (iron status, dialysis adequacy), while immutable variables such as gender, etiology of chronic renal failure (CRF) and age have been insufficiently explored.

[Tuberculosis in hemodialysis patients and evaluation of exposures].

Three cases of tuberculosis in hemodialysis patients are described. All of them had an insidious presentation: a pulmonary form, a pleural form and a lymphadenitis form of the disease. The three cases presented risk factors associated and in two out of the three the detection of the team was achieved during the first three months of hemodialysis therapy (one had to undertake hemodialysis again, after disfunction of renal transplant).

[Diagnosis and prevention of tuberculosis in hemodialysis patients. a new old problem?].

Patients with chronic renal failure undergoing hemodialysis are at increased risk of developing tuberculosis because of impaired cellular immunity. Most cases are due to reactivation of disease and are known to develop the complication of extrapulmonary tuberculosis more frequently than the general population, and this makes the disease difficult to diagnose, delaying the establishment of appropiate therapy. We evaluated 39 patients undergoing hemodialysis treatment in the course of a 3 year period, therewere.

[Eosinophilic ulcer of the oral mucosa: 11 cases].

Background: The eosinophilic ulcer is a lesion of the oral mucosa, that has been infrequently described in the literature. This is a benign and self-limiting lesion of unknown origin.

Case Reports: In this article, eleven new cases of eosinophilic ulcer of the oral mucosa are presented.

[Risk of deep infection in first-intention total hip replacement. Evaluation concerning a continuous series of 790 cases].

Objective: Deep infections of the operative site is a rare but serious complication of first intention total hip arthroplasties. French data on infections are sparse. We studied the incidence, characteristics and potential risk factors for these infections in a consecutive series of 790 total hip arthroplasties performed as first intention implantations in a University Hospital in France.

Structural organization of the enteric nervous system in the cattle esophagus revealed by wholemount immunohistochemistry.

In ruminants the motility patterns of the esophageal tube are characterized by physiological regurgitations including both anterograde and retrograde peristaltic movements. These complex motor functions require an elaborated enteric nervous system (ENS) for the generation of the underlying intrinsic reflex circuits. The structural organization of the esophageal ENS was studied in fetuses of cattle (n=6) by means of wholemount preparations obtained from different segments of the esophagus.

Subcutaneous nodules in Whipple's disease.

Background: Cutaneous findings other than hyperpigmentation are rare in Whipple's disease.

Case Report: We present the case of a 59-year-old man previously diagnosed with Whipple's disease by duodenal biopsy, who developed red-brown, painful, subcutaneous nodules on the buttocks, thighs, arms and legs. Biopsy of these nodules showed a septal panniculitis and foamy macrophages containing PAS-positive, diastase resistant intracytoplasmic material, characteristic of Whipple's disease and similar to that observed in the duodenal biopsy.

[Recurrent hallux valgus treated with metatarsophalangeal arthrodesis. A series of 32 patients].

Purpose Of The Study: We reviewed a series of 32 cases of recurrent hallux valgus treated by great toe metatarsophalangeal arthrodesis with a minimal 5-year follow-up.

Material And Method: Mean delay from the first surgical procedure and revision surgery was 11 years. All patients complained of forefoot pain.