Publications by authors named "Vivek Sehra"
Article Synopsis
- Liver metastases often resist immune checkpoint inhibitor (ICI) therapy, and regulatory T cells (Tregs) in the liver may contribute to this resistance, but their specific role is not well understood.* -
- The study utilized flow cytometry and RNA sequencing to analyze the behavior of hepatic Tregs, revealing a unique population that grows significantly in response to ICI treatment, regardless of tumor presence.* -
- The findings suggest that a specific subpopulation of CD29 Tregs in the liver is crucial for the enhanced suppression and resistance to ICI therapy, indicating their potential as targets for improving treatment outcomes.*
The spatial organization of various cell types within the tissue microenvironment is a key element for the formation of physiological and pathological processes, including cancer and autoimmune diseases. Here, we present S-CIMA, a weakly supervised convolutional neural network model that enables the detection of disease-specific microenvironment compositions from high-dimensional proteomic imaging data. We demonstrate the utility of this approach by determining cancer outcome- and cellular-signaling-specific spatial cell-state compositions in highly multiplexed fluorescence microscopy data of the tumor microenvironment in colorectal cancer.
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