Publications by authors named "Vivanna M Van Deerlin"
Article Synopsis
- Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease linked to abnormal tau protein accumulation, and previous studies were limited in exploring rare genetic variants due to the use of genotype arrays.* -
- In this study, whole genome sequencing (WGS) on a large cohort allowed researchers to confirm known genetic loci related to PSP and discover new associations, particularly highlighting a different role for the APOE ε2 allele compared to Alzheimer's disease.* -
- The findings expand knowledge of PSP's genetic underpinnings and identify potential targets for future research into the disease's mechanisms and treatments.*
Article Synopsis
- Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease linked to tau protein accumulation, and previous studies using genotype arrays overlooked important genetic variations like rare variants and structural changes.* -
- This study utilized whole genome sequencing (WGS) involving 1,718 PSP patients and 2,944 controls, confirming known genetic markers and discovering new associations, including the unique role of the ε2 allele as a risk factor.* -
- The findings from this research advance the understanding of PSP genetics, highlighting potential new targets for disease mechanisms and treatment strategies.*
Objective: We retrospectively compared the CT findings of consecutive viral and bacterial lower respiratory tract infections (LRTIs) to determine their imaging appearance and any definable differences among the causative viruses and between the viral and bacterial infections.
Materials And Methods: Imaging features of LRTI caused by influenza virus, respiratory syncytial virus (RSV), parainfluenza, adenovirus, and bacteria over a 33-month period were reviewed by three radiologists blinded to clinical and diagnostic information. Individual CT features and the dominant pattern of infection were recorded for each examination.
Objective: This study aimed to determine whether computed tomographic (CT) findings can distinguish viral lower respiratory tract illness (LRTI) from other conditions.
Methods: Three radiologists reviewed CT images of patients with LRTI who underwent testing for respiratory viral infection. Imaging findings in subjects with positive viral assays were compared with subjects with negative assays.