Publications by authors named "Vittorio Silvestri"
Article Synopsis
- The study aimed to assess the thickness of the macular retina and central choroid in a group of Ghanaians and compare these measurements to those of individuals with European and other African ancestries.
- It involved 42 Ghanaians, 37 Europeans, and an additional 1,427 subjects of African ancestry, using OCT scans to gather data on retinal thickness.
- Results showed that Ghanaians' macular retina and central choroid were significantly thinner than those of Europeans, with age and sex also influencing thickness, highlighting that established norms for retinal thickness may not apply to all populations.
Article Synopsis
- - A study was conducted to examine vitreomacular interface abnormalities (VMIA) using SD-OCT in Ghanaian adults aged 50 and older, focusing on their correlation with age-related macular degeneration (AMD) grade.
- - Out of 718 participants, 624 (mainly females) had their eye health assessed, revealing that a majority displayed no posterior vitreous detachment (PVD), while only a small percentage exhibited VMIA.
- - Results indicated that VMIA are prevalent among Africans, but PVD appears less common compared to Caucasians, and there was no significant link found between VMIA and AMD grade.
Article Synopsis
- West African crystalline maculopathy (WACM) features crystal-like deposits in the macula, with a study analyzing its characteristics and possible biological factors among a group of participants with this condition.* -
- The study involved 53 participants, predominantly aged around 68, and utilized various methods including medical histories, exams, and imaging to evaluate the presence and distribution of crystals.* -
- Findings showed WACM in 106 eyes with a notable link to the complement factor H (CFH) 402H genetic variant, while factors such as age and sex showed no significant associations.*
Article Synopsis
- The study aimed to analyze the foveal pit structure in a Ghanaian population and compare it with a Caucasian group, assessing age-related changes in both.
- Optical coherence tomography scans of 84 Ghanaians and 37 Caucasians were used to measure the foveal pit's depth, width, slope, and volume, factoring in variables like age, sex, and ethnicity.
- Results revealed significant differences in the foveal morphology between the two groups, with Ghanaians exhibiting greater width and volume, especially in women, highlighting the importance of these anatomical variations in understanding retinal diseases among different ethnicities.
Article Synopsis
- The study evaluated how dietary patterns (DP) affect the risk of age-related macular degeneration (AMD) in older women, using data from the Irish Nun Eye Study involving over 1,200 participants.
- Two main dietary patterns were identified: a 'healthy' pattern (rich in oily fish, whole grains, and fruits) and an 'unhealthy' pattern (high in fats and sugars).
- No significant link was found between either dietary pattern and AMD risk, suggesting the need for more research on dietary influences on AMD in broader populations.
Article Synopsis
- - A study conducted with 1033 older Irish women found that an unhealthy dietary pattern is linked to lower kidney function and higher risk of chronic kidney disease.
- - The research showed that those who followed an unhealthy diet had a mean reduction in kidney function of -6 ml/min/1.73 m compared to those on a healthier diet.
- - Interestingly, adherence to a healthy dietary pattern did not show any association with kidney function or chronic kidney disease in the study's adjusted analyses.
Background: Chronic kidney disease (CKD) and hypertension are global public health problems associated with considerable morbidity, premature mortality and attendant healthcare costs. Previous studies have highlighted that non-invasive examination of the retinal microcirculation can detect microvascular pathology that is associated with systemic disorders of the circulatory system such as hypertension. We examined the associations between retinal vessel caliber (RVC) and fractal dimension (DF), with both hypertension and CKD in elderly Irish nuns.
View Article and Find Full Text PDFPurpose: To evaluate the relationship between retinal vascular caliber (RVC), iris color, and age-related macular degeneration (AMD) in elderly Irish nuns.
Methods: Data from 1233 participants in the cross-sectional observational Irish Nun Eye Study were assessed from digital photographs with a standardized protocol using computer-assisted software. Macular images were graded according to the modified Wisconsin Age-related Maculopathy Grading System.
Background: Age-related macular degeneration (AMD) and Alzheimer's disease (AD) share several features, including the presence of extracellular abnormal deposits associated with neuronal degeneration, drusen, and plaques, respectively. Investigation of any association of AMD and specifically AD is worthwhile but has rarely been done.
Objectives: The aim of this study was to determine the prevalence of AMD in subjects with AD in comparison with an age-matched cognitively normal cohort.