Reduced expression of in differentiated thyroid cancer, the contribution of CPG methylation, and their clinical relevance.

Introduction: Forkhead box E1 () is a transcription factor with a crucial role in thyroid morphogenesis and differentiation. Promoter hypermethylation downregulates expression in different tumor types; nevertheless, its expression and relationship with methylation status in differentiated thyroid cancer (DTC) remain unclear.

Methods: A total of 33 pairs of matched samples of PTC tumors and non-tumors were included.

Case Report: Functional Analysis and Neuropsychological Evaluation of Dyshormonogenetic Fetal Goiter in Siblings Caused by Novel Compound Hyterozygous TPO Gene Mutations.

Introduction: It is rare for a euthyroid mother to carry a child with a fetal goiter. However, cases of congenital hypothyroidism (CH) caused by thyroid dyshormonogenesis have been reported. Even though gene mutations associated with fetal goiter have been reported in a few studies, the effects on intellectual development have not been investigated.