Publications by authors named "Vitoria Helena de Souza Campos"
Effect of spirulina on risk of hospitalization among patients with COVID-19: the TOGETHER randomized trial.
Am J Clin Nutr
September 2024
Background: Algae-derived nutraceuticals, such as spirulina, have been reported to have biological activities that may minimize clinical consequences to COVID-19 infections.
Objectives: This study aimed to determine whether spirulina is an effective treatment for high-risk patients with early COVID-19 in an outpatient setting.
Methods: The TOGETHER trial is a placebo-controlled, randomized, platform trial conducted in Brazil.
Background: Previous trials have demonstrated the effects of fluvoxamine alone and inhaled budesonide alone for prevention of disease progression among outpatients with COVID-19.
Objective: To determine whether the combination of fluvoxamine and inhaled budesonide would increase treatment effects in a highly vaccinated population.
Design: Randomized, placebo-controlled, adaptive platform trial.
Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial.
Lancet Glob Health
January 2022
Article Synopsis
- Recent research suggests fluvoxamine may help prevent hospitalizations in patients with COVID-19, as studied in the TOGETHER trial involving symptomatic Brazilian adults.
- In this randomized, placebo-controlled trial, participants were assigned to receive either fluvoxamine (100 mg twice daily for 10 days) or a placebo, while treatment allocation was kept blind for all involved.
- Out of 9,803 screened patients, the trial included 741 on fluvoxamine and 756 on placebo, with findings indicating superior outcomes for fluvoxamine in reducing COVID-19 related hospitalizations.