Publications by authors named "Vitoria Barros Marques"
Article Synopsis
- The study explores the effects of ketoprofen and meloxicam, two common NSAIDs, on male reproductive health, focusing on epididymal duct contractions and sperm quality in rats.
- In vitro tests showed that meloxicam significantly reduced the contractions induced by noradrenaline, while both drugs negatively impacted testosterone levels and sperm production in vivo.
- Ketoprofen and meloxicam altered sperm parameters, with meloxicam delaying sperm transit in the epididymis, indicating potential reproductive issues linked to these medications.
Intestinal mucositis (IM) is a common side effect of 5-fluorouracil (5-FU)-based chemotherapy, which negatively impacts therapeutic outcomes and delays subsequent cycles of chemotherapy resulting in dose reductions and treatment discontinuation. In search of new pharmacological alternatives that minimize your symptoms, this work set out to study the effect of losartan (LOS), a receptor type I (AT1) angiotensin II antagonist, on intestinal mucositis induced by 5-FU. Intestinal mucositis was induced by a single intraperitoneal administration of 5-FU (450 mg/kg) in Swiss mice.
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