Publications by authors named "Vitor S Ferreira"
Article Synopsis
- The study aimed to assess how a topical emulsion containing pyrrolidine dithiocarbamate (EcPDTC) affects skin stress and inflammation caused by UVB exposure.
- Mice received EcPDTC or a control emulsion at various times relative to UVB exposure, with several methods used to measure oxidative stress and inflammation in the skin.
- Results showed that EcPDTC treatment preserved antioxidant levels and significantly reduced indicators of inflammation and skin damage caused by UVB irradiation.
Ultraviolet B (UVB) irradiation may cause oxidative stress- and inflammation-dependent skin cancer and premature aging. Pyrrolidine dithiocarbamate (PDTC) is an antioxidant and inhibits nuclear factor-κB (NF-κB) activation. In the present study, the mechanisms of PDTC were investigated in cell free oxidant/antioxidant assays, in vivo UVB irradiation in hairless mice and UVB-induced NFκB activation in keratinocytes.
View Article and Find Full Text PDFPlants rich in antioxidant substances may be a promising strategy for preventing UV-induced oxidative and inflammatory damage of the skin. Pimenta pseudocaryophyllus is native to Brazil and presents flavonoids and other polyphenolic compounds in high concentration. Thus, the present study evaluated the possible effects of topical formulations containing P.
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