Publications by authors named "Vitor P Targhetta"
Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2.
J Venom Anim Toxins Incl Trop Dis
August 2021
The COVID-19 pandemic brought attention to studies about viral infections and their impact on the cell machinery. SARS-CoV-2, for example, invades the host cells by ACE2 interaction and possibly hijacks the mitochondria. To better understand the disease and to propose novel treatments, crucial aspects of SARS-CoV-2 enrolment with host mitochondria must be studied.
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- Histone deacetylases (HDACs) are crucial enzymes involved in various biological processes, and they are categorized into Zn-dependent and NAD-dependent types.
- Research has highlighted the significance of HDAC modulation particularly in neurodegenerative and psychiatric disorders, with an initial focus on Zn-dependent HDACs.
- Growing evidence suggests that NAD-dependent HDACs, known as sirtuins, are also vital players in these conditions and could be promising pharmacological targets, especially given their reduced levels in central nervous system disorders leading to increased pathology.