Publications by authors named "Vitor Carneiro de Vasconcelos Gama"
Controversies in immunotherapy for anti-NMDA receptor encephalitis: a scoping review with a proposal of operational definitions.
Neurol Sci
December 2023
Anti-NMDA receptor encephalitis (NMDARE), an autoimmune encephalitis associated with autoantibodies against the N-methyl-D-aspartate (NMDA) receptor, affects predominantly young women and is associated with psychiatric symptoms, seizures, movement disorders, and autonomic instability. Traditional treatments of anti-NMDA receptor encephalitis involve corticosteroids, intravenous immunoglobulin, plasmapheresis, cyclophosphamide, and rituximab. However, many controversies remain in the treatment for NMDA receptor encephalitis, such as optimal timing and combination of different immunotherapies, the role of newer strategies (e.
View Article and Find Full Text PDFPathophysiology and Treatment of Lipid Abnormalities in Cerebrotendinous Xanthomatosis: An Integrative Review.
Brain Sci
June 2023
Article Synopsis
- - Cerebrotendinous xanthomatosis (CTX) is a genetic disorder marked by a deficiency in sterol 27-hydroxylase, leading to dangerous buildups of cholestanol and bile alcohols in the brain, tendons, and nerves.
- - A review of literature highlighted that CTX patients typically show elevated cholestanol levels while having normal or low serum cholesterol levels; this dyslipidemia may indicate increased risk for atherosclerosis and cardiovascular issues.
- - The study suggests the potential use of cholesterol metabolites, like bile alcohols, as follow-up markers for monitoring CTX due to their relationship with abnormal lipid profiles and associated clinical symptoms.
Cerebrotendinous Xanthomatosis represents a rare and underdiagnosed inherited neurometabolic disorder due to homozygous or compound heterozygous variants involving the gene. This bile acid metabolism disorder represents a key potentially treatable neurogenetic condition due to the wide spectrum of neurological presentations in which it most commonly occurs. Cerebellar ataxia, peripheral neuropathy, spastic paraparesis, epilepsy, parkinsonism, cognitive decline, intellectual disability, and neuropsychiatric disturbances represent some of the most common neurological signs observed in this condition.
View Article and Find Full Text PDFCorrelation between ABO blood type, susceptibility to SARS-CoV-2 infection and COVID-19 disease severity: A systematic review.
Hematol Transfus Cell Ther
November 2022
Objectives: To verify the association between the ABO blood type and the risk of SARS-CoV-2 infection and COVID-19 disease severity.
Methods: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), using the 2020 PRISMA Checklist and flow diagram, and articles selected for review were analyzed using the Newcastle-Ottawa Quality Rating Scale. The research question was: "Would the ABO blood group influence the risk of infection and clinical course of patients infected with SARS-CoV-2?", The following databases were used: Embase, PubMed, Virtual Health Library (VHL), Web of Science, ScienceDirect and Scopus.