Publications by authors named "Vito Papic"
Neuropharmacology
March 2025
Article Synopsis
- Parkinson's disease (PD) exhibits a wide range of symptoms, complicating the translation of treatment efficacy from animal models to humans, suggesting that current models may not fully capture all PD characteristics.
- This project investigates whether metabolic dysfunction, induced by administering streptozotocin directly into the striatum of rats, can mimic the symptoms of PD typically seen in patients, focusing on cognitive and motor functions.
- Results showed that rats given streptozotocin bilaterally experienced significant motor and cognitive impairments alongside disrupted brain metabolism, indicating that this method could provide a better animal model for studying PD and testing new therapies.
