Publications by authors named "Vito Metallo"
Article Synopsis
- The treatment sequence for breast cancer has traditionally involved adjuvant chemotherapy followed by adjuvant radiotherapy, but advancements in research have prompted questions about optimizing this order.
- Recent studies have explored various sequencing strategies like sequential, concomitant, and sandwich approaches, evaluating their effectiveness and safety for over 8,000 patients across multiple research studies.
- Despite the extensive analysis, a definitive best practice for the sequencing of adjuvant chemotherapy and radiotherapy remains undetermined, highlighting the need for further investigation in this area.
Purpose: We administered a new breast cancer (BC) adjuvant therapy sequence that delivered postoperative radiotherapy (PORT) before chemotherapy (CT). Our aim was to assess the gain in time to start PORT and the G2-G3 acute-subacute toxicity rate of whole breast adjuvant hypofractionated radiotherapy (AH-RT) administered up-front to the third-generation adjuvant CT (A-CT) in high-risk nodal positive BC in a preliminary report at 2 years.
Methods: This retrospective study analysed the duration of treatment and safety of AH-RT administered up-front to A-CT in high-risk nodal positive BC patients (pts).