Publications by authors named "Vito Mantese"
Background: Ascending and thoracic aortic dissections progress into thoracoabdominal aneurysms 20-40% of the time, due to the initial aortic injury with associated weakness of the aortic wall. The increased firmness of the intimal flap usually results in a collapsed true lumen that does not spontaneously reexpand even with progressive dilatation of the aorta. In an effort to identify a safe and effective treatment path for this complex disease process, we present 4 cases illustrating successful sequential thoracic endovascular aortic repair (TEVAR) and fenestrated endovascular aortic repair (FEVAR).
View Article and Find Full Text PDFBackground: In the Carotid Revascularization Endarterectomy versus Stenting Trial, we found no significant difference between the stenting group and the endarterectomy group with respect to the primary composite end point of stroke, myocardial infarction, or death during the periprocedural period or any subsequent ipsilateral stroke during 4 years of follow-up. We now extend the results to 10 years.
Methods: Among patients with carotid-artery stenosis who had been randomly assigned to stenting or endarterectomy, we evaluated outcomes every 6 months for up to 10 years at 117 centers.
Background: The Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) is a multicenter randomized trial of stenting versus endarterectomy in patients with symptomatic and asymptomatic carotid disease. This study assesses management of vascular risk factors.
Methods And Results: Management was provided by the patient's physician, with biannual monitoring results collected by the local site.
Objective: Outcomes in the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) did not differ between carotid artery stenting (CAS) and carotid endarterectomy (CEA) for the composite primary end point of stroke, myocardial infarction (MI), or death during the periprocedural period or ipsilateral stroke within 4 years. Rigorous credentialing and training of interventionists, including vascular surgeons, were required for the randomization phase of CREST. Because the lead-in phase of CREST had suggested higher perioperative risks after CAS performed by vascular surgeons, the purpose of this analysis was to examine differences in outcomes after randomization between CAS and CEA performed by vascular surgeons.
View Article and Find Full Text PDFA 66-year-old man with an abdominal aortic aneurysm previously repaired with an endovascular stent graft presented to our facility with worsening midabdominal and back pain. Previous postoperative surveillance computed tomography scans were unremarkable, showing excellent stent-wall apposition and a shrinking aneurysm sac; however, imaging done on his arrival identified a contained rupture at the level of the celiac artery containing a perforating suprarenal stent. We repaired this rupture with a surgeon-modified fenestrated stent graft.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the genetic and environmental risk factors for asthma by analyzing data from 5,416 individuals of different ethnic backgrounds, including European American, African American, and Latino ancestry, and replicating findings in 12,649 additional individuals.
- - Researchers identified five genetic loci linked to asthma susceptibility, confirming four previously known associations and discovering a new one at the PYHIN1 gene, specific to individuals of African descent.
- - The findings highlight that while some genetic risk factors for asthma are consistent across various ancestries, there are also specific associations that vary depending on ethnic background, suggesting a complex genetic landscape for the disease.
Background And Purpose: Carotid artery stenosis causes up to 10% of all ischemic strokes. Carotid endarterectomy (CEA) was introduced as a treatment to prevent stroke in the early 1950s. Carotid stenting (CAS) was introduced as a treatment to prevent stroke in 1994.
View Article and Find Full Text PDFObjectives: Determine the prevalence and clinical significance of deep venous thrombosis (DVT) in the asymptomatic contralateral extremity of patients referred to the vascular laboratory with unilateral symptoms and DVT confirmed by duplex scan.
Method: From December 2003 to October 2006, a total of 4813 patients were referred to our vascular laboratory for unilateral venous duplex scans. We prospectively studied 239 patients who were found to have acute DVT and had unilateral symptoms.