Publications by authors named "Vito Ag Ricigliano"
Background: Choroid plexus (ChP) enlargement is an emerging radiological biomarker in multiple sclerosis (MS).
Objectives: This study aims to assess ChP volume in a large cohort of patients with radiologically isolated syndrome (RIS) versus healthy controls (HC) and explore its relationship with other brain volumes, disease activity, and biological markers.
Methods: RIS individuals were included retrospectively and compared with HC.
Article Synopsis
- The study aimed to assess the importance of changes in myelin content in both cortical and white matter lesions in patients with multiple sclerosis (MS) using two imaging techniques: magnetisation transfer imaging (MTI) and 11C-PiB-PET.
- Researchers analyzed data from 19 MS patients and 7 healthy controls over a follow-up period of 2-4 months, creating individual maps to calculate levels of demyelination and remyelination.
- Results showed that greater remyelination correlated with shorter disease duration and significantly influenced clinical scores, suggesting that these personalized myelin indices could improve the evaluation of potential treatments in clinical trials.
Article Synopsis
- Diffusion-weighted H magnetic resonance spectroscopy (DW-MRS) measures creatine-phosphocreatine diffusivity in the brain, which can indicate energy dysfunction in multiple sclerosis (MS).
- The study included 20 MS patients and 13 healthy controls, examining the relationship between thalamic ADC(tCr) and damage in thalamo-cortical tracts using various imaging metrics.
- Results showed that lower thalamic ADC(tCr) in MS patients was linked to higher mean and radial diffusivity in thalamo-cortical tracts, indicating that energy metabolism issues in the thalamus correlate with structural damage in connected neural pathways.