Application of film-casting technique to investigate drug-polymer miscibility in solid dispersion and hot-melt extrudate.

Determination of drug-polymer miscibility is critical for successful development of solid dispersions. This report details a practical method to predict miscibility and physical stability of drug with various polymers in solid dispersion and, especially, in melt extrudates by applying a film-casting technique. Mixtures of itraconazole (ITZ) with hydroxypropylmethylcellulose phthalate (HPMCP), Kollidon(®) VA 64, Eudragit(®) E PO, and Soluplus(®) were film-casted, exposed to 40°C/75% RH for 1 month and then analyzed using differential scanning calorimetry (DSC), powder X-ray diffractometry, and polarized light microscopy (PLM).

Effect of carbamazepine on viscoelastic properties and hot melt extrudability of Soluplus ®.

The purpose of this study was to apply viscoelastic properties of polymer and drug-polymer mixtures to determine processing conditions for the preparation of amorphous solid dispersion by melt extrusion. A poorly water-soluble drug, carbamazepine (CBZ), was mixed with Soluplus(®) as the carrier. Torque analysis using a melt extruder was performed at 10, 20 and 30% w/w drug concentrations and the effect of barrel temperature was studied.

[Surgical hand disinfektion with a solution of performic acid (author's transl)].

Disinfection with a solution of performic acid has an intensive bactericidal and sporocidal effect. This method is simple and prompt in service, is free from danger, inexpensive and can be used everywhere.

Cholericidic effect of some intestinal disinfectants.

Several compounds have been found which are markedly more effective and more economical as chemoprophylactic agents than the tetracycline compounds traditionally used in cholera-endemic areas. Some synergetically acting combinations were shown to exert by several orders of magnitude higher vibriocidal potency than the sum of potency of the compounds when applied singly. In the presence of human intestinal content, however, markedly higher concentrations are needed to exert the proper vibriocidic effect than in aqueous medium.