Association of Gene Variants with Adverse Perinatal Outcomes in COVID-19 Infected Pregnant Women in Kazakhstan.

SARS-CoV-2 utilizes the angiotensin-converting enzyme 2 (ACE2) receptors located on membranes to enter host cells. Nevertheless, the gene primarily encodes for a zinc metalloproteinase, which is a part of the renin-angiotensin system (RAS). ACE2 downregulation results in the deregulation of RAS in favor of pro-fibrosis, pro-apoptosis, oxidative stress, pro-inflammation, aldosterone production and release, and blood vessel contraction axis.

Study of the Basic Labor Activity of a General Practitioner Using the Time-Keeping Method on the Example of Polyclinics of the City of Karaganda, Kazakhstan.

Objective: To study and analyze the working time distribution of general practitioners at the outpatient appointment in polyclinics of Karaganda, Kazakhstan.

Materials And Methods: The time spent by the general practitioner on all activities was studied by the timing method.

Results: a) general practitioners spend a great part of working time for the documentation and organizational measures; therefore, they spend less time for patients; b) it is necessary to maximally unload the doctor from working with documentation.