Human pegivirus isolates characterized by deep sequencing from hepatitis C virus-RNA and human immunodeficiency virus-RNA-positive blood donations, France.

Human pegivirus (HPgV, formerly GBV-C) is a member of the genus Pegivirus, family Flaviviridae. Despite its identification more than 20 years ago, both natural history and distribution of this viral group in human hosts remain under exploration. Analysis of HPgV genomes characterized up to now points out the scarcity of French pegivirus sequences in databases.

Molecular epidemiology of KI and WU polyomaviruses in healthy blood donors, south-eastern France.

The epidemiology of human polyomaviruses KI (KIPyV) and WU (WUPyV) in healthy populations is described poorly in the literature. The frequency of KIPyV and WUPyV viraemia was evaluated in a cohort of blood donors from south-eastern France. Plasma samples (n=640) were investigated for the presence of KIPyV/WUPyV DNA using a conserved real-time PCR detection system (VP2 gene).

Positive association of DRB1 04 and DRB1 15 alleles with Fya immunization in a Southern European population.

Background: Anti-Fy(a) has been implicated in hemolytic transfusion reactions. However, not all Fy(a-) patients develop anti-Fy(a) after transfusion with 1 unit of blood [Fy(a+)]. This study was designed to identify HLA-DRB1 alleles associated with a predisposition to Fy(a) immunization after blood transfusion.

High levels of molecular polymorphism at the KIR2DL4 locus in French and Congolese populations: impact for anthropology and clinical studies.

To characterize KIR2DL4 molecular polymorphism, a cloning-sequencing protocol was performed in 49 French and 52 Teke Congolese individuals. These two populations exhibited high levels of genetic diversity for KIR2DL4, possibly under the influence of natural selection. The most frequent alleles in French individuals (i.