Publications by authors named "Viswanathan M"

Purpose: To evaluate the incidence, refractive error (RE) association, and distribution of atraumatic rhegmatogenous retinal detachment (RRD) in U.S. military service members (SMs).

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Importance: Fragility fractures result in significant morbidity.

Objective: To review evidence on osteoporosis screening to inform the US Preventive Services Task Force.

Data Sources: PubMed, Embase, Cochrane Library, and trial registries through January 9, 2024; references, experts, and literature surveillance through July 31, 2024.

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Background: Telehealth services can increase access to care by reducing barriers. Telephone-administered care, in particular, requires few resources and may be preferred by communities in areas that are systemically underserved. Understanding the effectiveness of audio-based care is important to combat the current mental health crisis and inform discussions related to reimbursement privileges.

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A new nuclear Overhauser enhancement (NOE)-mediated saturation transfer MRI signal at -1.6 ppm, potentially from choline phospholipids and termed NOE(-1.6), has been reported in biological tissues at high magnetic fields.

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Endocrine-disrupting chemicals (EDCs) play an important role in the incidence of type-2 diabetes. Di-2-ethyl hexyl Phthalate (DEHP) is one of the endocrine-disrupting chemicals used as a plasticizer to impart flexibility and softness to plastic-containing materials. Mono-2-ethylhexyl Phthalate (MEHP), a DEHP's primary metabolite, is preferentially absorbed once metabolized.

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Replies to comments made by Mattos et al. (see record 2025-49982-003) on the original article (see record 2024-19816-001). Mattos et al.

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Objectives: To systematically evaluate definitions of "racial health equity" (RHE) and related terms within health-related academic literature.

Study Design And Setting: We systematically evaluated definitions of RHE and related terms within health-related academic articles. Articles published in English were included, and no date restrictions were imposed.

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Myosin storage myopathy (MSM) is a rare skeletal muscle disorder caused by mutations in the slow muscle/β-cardiac myosin heavy chain (MHC) gene. MSM missense mutations frequently disrupt the tail's stabilizing heptad repeat motif. Disease hallmarks include subsarcolemmal hyaline-like β-MHC aggregates, muscle weakness, and, occasionally, cardiomyopathy.

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Article Synopsis
  • - The study aimed to find evidence syntheses of health interventions that focus on racial health equity, examining the use of equity-focused frameworks and logic models.
  • - Researchers conducted a search across multiple sources, including bibliographic databases and interviews, to identify effective frameworks, finding only two out of 153 reviews used logic models to explain interventions.
  • - The results indicated a scarcity of logic models and frameworks in these studies, highlighting an urgent need for more comprehensive frameworks to better guide the research and interpretation of findings in racial health equity.
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Objectives: Systematic reviews hold immense promise as tools to highlight evidence-based practices that can reduce or aim to eliminate racial health disparities. Currently, consensus on centering racial health equity in systematic reviews and other evidence synthesis products is lacking. Centering racial health equity implies concentrating or focusing attention on health equity in ways that bring attention to the perspectives or needs of groups that are typically marginalized.

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Article Synopsis
  • The study evaluated systematic reviews of interventions aimed at improving racial health equity among racialized populations, particularly those published between January 2020 and January 2023.
  • Analysis of 157 reviews revealed that only 14% addressed the role of racism in health disparities, and 67% merely summarized studies without proper synthesis, with many using biased methods for effect sizes.
  • The findings highlight a need for better research quality, comprehensive examination of racism, and a focus on structural interventions to enhance opportunities for racialized groups in addressing health inequities.
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Article Synopsis
  • The study aims to explore how health-related syntheses address racial health equity and how they engage diverse interest holders in the process.
  • Out of the 157 syntheses reviewed, only 29 (18%) reported engaging stakeholders, often lacking detailed methods or outcomes of the engagement, particularly for racially diverse groups.
  • The review highlights significant gaps in the understanding of effective engagement strategies for promoting racial health equity and calls for more specific guidance on involving diverse populations in health research.
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Article Synopsis
  • The study aimed to define and address racial health equity within systematic reviews by exploring how to effectively staff, conduct, and evaluate these reviews.
  • Twenty-nine participants, including patients and healthcare professionals, discussed the importance of social determinants of health and the role of community members in the review process.
  • To ensure racial health equity in systematic reviews, stakeholders called for adjustments in funding, methods, and communication strategies, emphasizing the need for resources and collaboration among interest holders.
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Amide proton transfer (APT) imaging, a technique sensitive to tissue pH, holds promise in the diagnosis of ischemic stroke. Achieving accurate and rapid APT imaging is crucial for this application. However, conventional APT quantification methods either lack accuracy or are time-consuming.

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Diamond-type silicon has a work function of ≈4.8 eV, and conventional n- or p-type doping modifies the value only between 4.6 and 5.

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Purpose: To develop a SNR enhancement method for CEST imaging using a denoising convolutional autoencoder (DCAE) and compare its performance with state-of-the-art denoising methods.

Method: The DCAE-CEST model encompasses an encoder and a decoder network. The encoder learns features from the input CEST Z-spectrum via a series of one-dimensional convolutions, nonlinearity applications, and pooling.

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One of the biggest issues the world is currently experiencing is the scarcity of pure water due to the contamination of pure water by human activities. Highly efficient, semiconducting photocatalytic materials have great potential as future catalytic materials for facilitating the clean-up process of contaminated water. Among the many semiconductor photocatalysts, non-metal-doped zinc oxide (ZnO) nanoparticles have attracted special attention in the scientific field for environmental remediation applications.

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Importance: The United States Preventive Services Task Force (USPSTF) has considered the topic of prevention of child maltreatment multiple times over its nearly 40-year history, each time reaching the conclusion that the evidence is insufficient to recommend for or against interventions aimed at preventing this important health problem with significant negative sequelae before it occurs. In the most recent evidence review, which was conducted from August 2021 to November 2023 and published in March 2024, the USPSTF considered contextual questions on the evidence for bias in reporting and diagnosis of maltreatment in addition to key questions regarding effectiveness of interventions to prevent child maltreatment.

Observations: A comprehensive literature review found evidence of inaccuracies in risk assessment and racial and ethnic bias in the reporting of child maltreatment and in the evaluation of injuries concerning for maltreatment, such as skull fractures.

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Article Synopsis
  • Interventions targeting social needs like low income and housing instability are becoming more common in healthcare, but evidence on how to effectively implement these interventions on a larger scale is scarce.
  • The objective of the study was to evaluate the intensity and complexity of social needs interventions in randomized clinical trials (RCTs) and to determine if these trials measure the interventions' causal effects on health outcomes.
  • The review found 77 relevant RCTs involving over 135,000 participants, with most studies showing high intensity and complexity features, indicating a need for more thorough evaluation of their impacts.
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  • Accurate data extraction is crucial for valid evidence synthesis, and recent interest in large language models (LLMs) like Claude 2 and GPT-4 has raised questions about their effectiveness for this purpose.
  • In a comparison of these two LLMs on extracting data from PDFs of systematic review articles, Claude 2 achieved high accuracy (96.3%), while GPT-4 had a lower accuracy (68.8%) mainly due to the challenges of using a third-party PDF parsing plugin.
  • Although both models performed well in identifying missing data and generating correct information, the study emphasizes the need for human verification of LLM extractions and highlights limitations such as the study’s narrow focus and potential biases in the training data.
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Purpose: To develop a SNR enhancement method for chemical exchange saturation transfer (CEST) imaging using a denoising convolutional autoencoder (DCAE), and compare its performance with state-of-the-art denoising methods.

Method: The DCAE-CEST model encompasses an encoder and a decoder network. The encoder learns features from the input CEST Z-spectrum via a series of 1D convolutions, nonlinearity applications and pooling.

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  • The article details an affordable microwave synthesis method for fabricating MnMoO nanoflowers by adjusting factors like solvent, pH, microwave power, and duration, resulting in various nanostructures.
  • Characterization techniques such as XRD, FE-SEM, FT-IR, and UV-DRS were employed to assess the physical and chemical properties of the synthesized nanoflowers, confirming their crystallinity and unique morphology.
  • The synthesized MnMoO nanoflowers exhibited 85% photocatalytic activity in degrading methylene blue under visible light, with proposed mechanisms highlighting effective charge separation and stability for potential future environmental applications.
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Article Synopsis
  • Observational epidemiologic studies are important for understanding how environmental, occupational, and behavioral factors impact human health, and systematic reviews help guide policies based on these studies.
  • A new assessment tool called Risk Of Bias In Non-randomized Studies - of Exposures (ROBINS-E) has been created to evaluate the risk of bias in cohort studies examining the effects of specific exposures on outcomes.
  • ROBINS-E offers a structured method to assess bias through multiple domains using signaling questions, and aims to improve how biases are integrated into evidence synthesis and causal inference in research.
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