Composite Microgels Loaded with Doxorubicin-Conjugated Amine-Functionalized Zinc Ferrite Nanoparticles for Stimuli-Responsive Sustained Drug Release.

Purpose: The purpose of this study is to address the need for efficient drug delivery with high drug encapsulation efficiency and sustained drug release. We aim to create nanoparticle-loaded microgels for potential applications in treatment development.

Methods: We adopted the process of ionic gelation to generate microgels from sodium alginate and carboxymethyl cellulose.

Neuromodulation by nanozymes and ultrasound during Alzheimer's disease management.

Alzheimer's disease (AD) is a neurodegenerative disorder with complex pathogenesis and effective clinical treatment strategies for this disease remain elusive. Interestingly, nanomedicines are under extensive investigation for AD management. Currently, existing redox molecules show highly bioactive property but suffer from instability and high production costs, limiting clinical application for neurological diseases.

Self-Signal-Triggered Drug Delivery System for Tumor Therapy Using Cancer Cell Membrane-Coated Biocompatible MnO Nanocomposites.

In anti-cancer metastasis treatment, precise drug delivery to cancer cells remains a challenge. Innovative nanocomposites are developed to tackle these issues effectively. The approach involves the creation of manganese oxide (MnO) nanoparticles (NPs) and their functionalization using trisodium citrate to yield functionalized MnO NPs (F-MnO NPs), with enhanced water solubility, stability, and biocompatibility.

Redox-Responsive Comparison of Diselenide and Disulfide Core-Cross-Linked Micelles for Drug Delivery Application.

In this study, diselenide (Se-Se) and disulfide (S-S) redox-responsive core-cross-linked (CCL) micelles were synthesized using poly(ethylene oxide)--poly(furfuryl methacrylate) (PEO--PFMA), and their redox sensitivity was compared. A single electron transfer-living radical polymerization technique was used to prepare PEO--PFMA from FMA monomers and PEO-Br initiators. An anti-cancer drug, doxorubicin (DOX), was incorporated into PFMA hydrophobic parts of the polymeric micelles, which were then cross-linked with maleimide cross-linkers, 1,6-bis(maleimide) hexane, dithiobis(maleimido) ethane and diselenobis(maleimido) ethane via Diels-Alder reaction.

Dual cross-linked chitosan/alginate hydrogels prepared by Nb-Tz 'click' reaction for pH responsive drug delivery.

A novel physically and chemically double-crosslinked hydrogel derived from chitosan oligosaccharide/alginate (COS/Alg) was developed by using norbornene (Nb)-tetrazine (Tz) click reaction for ketoprofen delivery. The properties of the hydrogel were evaluated by rheological, FTIR, TGA, XRD, SEM, swelling and drug release studies. The Nb-Tz chemical cross-linking facilitated outstanding hydrophobic drug loading (44% wt/wt of ketoprofen) and sustained release through a hydrophobic interaction mechanism between the drug and the used polysaccharides.

Antibiofilm and antimicrobial efficacy evaluation of polypyrrole nanotubes embedded in aminated gum acacia based nanocomposite.

The sustainable development of natural polysaccharide-based hybrid composites is highly important for the effective replacement of metal nanoparticles in diverse applications. Here, polypyrrole nanotubes (PPyNTs) were embedded on the surface of aminated gum acacia (AGA) to produce ecofriendly nanocomposites for biomedical applications. The morphology of a PPyNT-enhanced AGA (PPyNT@AGA) hybrid nanocomposite was studied by scanning electron microscopy and transmission electron microscopy and their affirmed interactions were characterised by X-ray diffraction, Raman, Fourier transform-infrared and UV-visible spectroscopy.

Chitosan overlaid FeO/rGO nanocomposite for targeted drug delivery, imaging, and biomedical applications.

A hybrid and straightforward nanosystem that can be used simultaneously for cancer-targeted fluorescence imaging and targeted drug delivery in vitro was reported in this study. A chitosan (CS) polymer coated with reduced graphene oxide (rGO) and implanted with FeO nanoparticles was fabricated. The fundamental physicochemical properties were confirmed via FT-IR, XRD, FE-SEM, HR-TEM, XPS, and VSM analysis.

Preparation and characterization of positively surface charged zinc oxide nanoparticles against bacterial pathogens.

Solvothermal synthesis was used to investigate the formation of zinc oxide (ZnO) nanoparticles (NPs). A series of ZnO NPs was synthesized with different relative ratios of didodecyldimethylammonium bromide (DDAB) and zinc nitrate (ZN). The variation in the molarity influenced the crystallinity, size, and morphology of the obtained ZnO NPs.

Poly(Lactic Acid)/Zno Bionanocomposite Films with Positively Charged Zno as Potential Antimicrobial Food Packaging Materials.

A series of PLA/ZnO bionanocomposite films were prepared by introducing positively surface charged zinc oxide nanoparticles (ZnO NPs) into biodegradable poly(lactic acid) (PLA) by the solvent casting method, and their physical properties and antibacterial activities were evaluated. The physical properties and antibacterial efficiencies of the bionanocomposite films were strongly dependent on the ZnO NPs content. The bionanocomposite films with over 3% ZnO NPs exhibited a rough surface, poor dispersion, hard agglomerates, and voids, leading to a reduction in the crystallinity and morphological defects.

Biocompatible properties of nano-drug carriers using TiO-Au embedded on multiwall carbon nanotubes for targeted drug delivery.

Nanomaterial-based drug carriers have become a hot spot of research at the interface of nanotechnology and biomedicine because they allow efficient loading, targeted delivery, controlled release of drugs, and therefore are promising for biomedical applications. The current study made an attempt to decorate the multiwalled carbon nanotubes (MWCNT) with titanium dioxide‑gold nanoparticles in order to enhance the biocompatibility for doxorubicin (DOX) delivery. The successful synthesis of nano drug carrier (NDC) was confirmed by XRD, XPS and UV-Visible spectroscopy.

Synthesis and characterization of MWCNT/TiO/Au nanocomposite for photocatalytic and antimicrobial activity.

A novel combination of titanium oxide (TiO)/gold (Au)/multiwalled carbon nanotubes (MWCNTs) nanocomposite (NC) was synthesised by sol- gel method. MWCNT functionalisation by modified Hummers method. TiO/Au nanoparticles (NPs) were synthesised by biological method using bark extract.

Guazuma ulmifolia bark-synthesized Ag, Au and Ag/Au alloy nanoparticles: Photocatalytic potential, DNA/protein interactions, anticancer activity and toxicity against 14 species of microbial pathogens.

In the present study, we focused on a quick and green method to fabricate Ag, Au and Ag/Au alloy nanoparticles (NPs) using the bark extract of Guazuma ulmifolia L. Green synthesized metal NPs were characterized using different techniques, including UV-Vis spectroscopy, FT-IR, XRD, AFM and HR-TEM analyses. The production of Ag, Au and Ag/Au alloy NPs was observed monitoring color change from colorless to brown, followed by pink and dark brown, as confirmed by UV-Vis spectroscopy characteristic peaks at 436, 522 and 510nm, respectively.

Synthesis of cerium oxide nanoparticles using Gloriosa superba L. leaf extract and their structural, optical and antibacterial properties.

CeO2 nanoparticles (NPs) were green synthesized using Gloriosa superba L. leaf extract. The synthesized nanoparticles retained the cubic structure, which was confirmed by X-ray diffraction studies.