Publications by authors named "Vishwanathan B"
Article Synopsis
- Stereotactic ablative body radiation (SABR) is an effective treatment for liver cancer (HCC), but managing tumor movement is essential for accurate treatment delivery.
- * In a study involving 10 patients, researchers compared different imaging techniques (like maximum intensity projection and average intensity projection) to see how well they matched the comprehensive target volume created using all respiratory phases (ITV_all_phase).
- * The results showed that the all-phase 4DCT method provided the best accuracy for targeting liver tumors, highlighting the importance of using this approach to minimize treatment errors.
Article Synopsis
- The study projects that by 2040, around 161,000 patients in India will be eligible for particle therapy, indicating a growing demand for therapy facilities from 81-97 in 2020 to 121-146 by 2040.
- Economic analysis shows that while capital costs for particle therapy are higher than conventional treatments, the treatment price per patient fraction could be significantly lower than that in higher-income countries, making it more accessible.
- Despite challenges like resource limitations and the need for trained professionals, the research concludes that large-scale proton therapy is the most viable option, with a phased implementation strategy suggested to effectively tackle these barriers.
Background: There are very few prospective studies comparing simultaneous integrated boost versus sequential boost in the setting of definitive treatment modality of head and neck squamous cell cancer (HNSCC), especially in the Indian scenario.
Materials And Methods: We prospectively randomized 50 patients with biopsy-proven squamous cell carcinoma of the oropharynx, hypopharynx, and larynx malignancies, stage T1-3, enlarged node measuring ≤3 cm that are planned for definitive radiotherapy with chemotherapy into either hypo-fractionated simultaneous integrated (Hypo-SIB VMAT) boost arm or conventional (Conv-VMAT) boost arm.
Results: Most of the patients were men and aged less than 50 years.
Unlabelled: This study aimed to prospectively evaluate the impact of dose-escalated irradiation of nodal metastases on clinical outcomes compared to no boost in patients with node-positive, bulky, locally advanced cervical cancer (LACC) undergoing standard chemoradiation and MRI-based brachytherapy.
Methods: This comparative study included 161 patients with node-positive LACC treated with definitive chemoradiation and MRI-based brachytherapy. The prospective Boost arm accrued 71 patients to receive nodal boost either sequentially or simultaneously to an equivalent dose of 60 Gy.
Purpose: Image-guided adaptive brachytherapy (IGABT) recently has shown excellent clinical outcomes with superior local control and less toxicity. For IGABT, T2W (T2-weighted) MRI is the gold standard. However, studies have shown that target delineation with the same results in uncertainties, poor interobserver variabilities, and low conformity indices for high-risk clinical target volume contours.
View Article and Find Full Text PDFPurpose: The purpose of this series is to study the effectiveness of MRI based image-guided brachytherapy (IGBT) in Indian patients with cervical cancer who mostly present in later stages with bulky diseases.
Patients And Methods: 151 cervical cancer patients treated at our institution in last four years, with definitive chemoradiation followed by MRI-based brachytherapy were reviewed. With median follow up of 26 months, Kaplan Meier estimates at two years were calculated for local control (LC), pelvic control (PC), disease-free survival (DFS) and overall survival (OS).
Iron nanotube silica composite have been synthesized and studied through particle-size analysis, FTIR, SEM-EDX, TEM, XRD, UV, VSM, TGA-DTA and XPS techniques. The application of nanoframeworks as sustainable recyclable catalytic systems has been observed for azole cyclic ring organic transformations. The good reaction yields and characterization through (1)H NMR, (13)C NMR and mass analysis support the performance of the nanoframeworks.
View Article and Find Full Text PDFCoumarin class of organic compounds consists of 1,2-benzopyrone ring system as a basic parent scaffold. These benzopyrones are subdivided into alpha-benzopyrones and gammabenzopyrones; with coumarin class of compounds belonging to alpha-benzopyrones. Since the last few years, coumarins were synthesized in many of their derivative forms.
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