Publications by authors named "Vishnupriyan Kumar"
Article Synopsis
- * The development of OV therapies involves three key phases: designing the virus, producing it, and conducting preclinical tests to assess its effectiveness before clinical trials.
- * Factors influencing OV selection include the type of cancer, the virus's safety and effectiveness, and logistical issues in research and treatment settings.
Article Synopsis
- - CD8 T cells are crucial for fighting viruses, and type I interferons quickly activate them after viral exposure, leading to changes in their behavior.
- - The study reveals that exposure to reovirus activates naïve CD8 T cells within 24 hours, highlighting a previously overlooked role of these cells in the immune response.
- - The activation of naïve CD8 T cells is dependent on a protein called STAT1 and is influenced by a metabolic process involving nicotinamide phosphoribosyl transferase (NAMPT), suggesting new insights into immune responses to viruses.
Oncolytic reovirus preferentially targets and kills cancer cells via the process of oncolysis, and additionally drives clinically favorable antitumor T cell responses that form protective immunological memory against cancer relapse. This two-prong attack by reovirus on cancers constitutes the foundation of its use as an anticancer oncolytic agent. Unfortunately, the efficacy of these reovirus-driven antitumor effects is influenced by the highly suppressive tumor microenvironment (TME).
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