Imaging-based Biomarkers as Predictors of Response to Anti-VEGF Therapy in Idiopathic Choroidal Neovascularization.

Purpose: The purpose of this study was to identify biomarkers that predict the response of treatment-naive idiopathic choroidal neovascularization (iCNV) to anti-VEGF treatment.

Methods: Fourteen eyes diagnosed with iCNV underwent a dilated fundus examination, Swept Source Optical Coherence Tomography (SS-OCT) and Optical Coherence Tomography - Angiography (OCT-A), and were given an anti-VEGF injection. The same examinations were repeated at every follow-up visit.

Scleral tunnel with conjunctival autograft for rescue management of extruded haptic: Surgical technique and review of literature.

Extrusion of haptic is a rare complication after intra-scleral haptic fixation of intraocular lens (SF-IOL). Various techniques described for its management such as autologous scleral patch, cauterization of exposed haptic, reattempting the glued IOL and IOL explant have their own limitations. Presently, we describe a simple rescue technique for management of such situations.

Descemetocele.

A corneal descemetocele, the anterior herniation of an intact Descemet membrane through an overlying stromal defect, is a rare, but serious outcome of progressive corneal ulceration and mandates urgent intervention owing to the imminent risk of perforation. Various ocular and systemic abnormalities that can lead to the formation of descemetocele include microbial keratitis, neurotrophic keratopathy, dry eye disorders, and corneal inflammation associated with immune-mediated disorders. The primary aim of management of a descemetocele remains prompt restoration of ocular integrity to prevent the rupture of the Descemet membrane and further complications.

Congenital simple hamartoma of the retinal pigment epithelium: What is the probable cause?

Congenital simple hamartoma of the retinal pigment epithelium is localized to the retinal tissue only with variable amount of surface extension. With consistent morphological and OCT features of the lesion around fovea, it appears that some of the embryologically undifferentiated ectopic progenitor cells destined for RPE within the retinal tissue may not undergo any further differentiation due to lack of necessary homeostatic factors leading to only hyperplasia and accumulation of the cells within the retina leading to simple hamartoma.