Disseminated Histoplasmosis Presenting as Pyrexia of Unknown Origin in a Rheumatoid Arthritis Patient.

We present a case of a 56-year-old female with rheumatoid arthritis (RA) who has been on methotrexate for 9 years and has been complaining of high-grade fever for the past 1 month with no localizing signs and symptoms. She was thoroughly evaluated before being labeled as pyrexia of unknown origin. Histoplasmosis was suspected after bone marrow aspiration smear examination.

Glassy relaxation in a de Vries smectic liquid crystal consisting of bent-core molecules.

We report experimental investigations of a liquid crystal comprising thiophene-based achiral bent-core banana shaped molecules. The compound exhibits the following phase sequence on cooling: Isotropic (517.4 K), N (514.

Unlocking the plant ER stress code: IRE1-proteasome signaling cohort takes the lead.

In the intricate landscape of cellular function, proper protein folding is pivotal for cellular processes, particularly within the endoplasmic reticulum (ER). In a recent study, Ko et al. reveal a signaling role for inositol-requiring enzyme 1 (IRE1) in ER stress and identify PHOSPHATASE TYPE 2CA (PP2CA)-INTERACTING RING FINGER PROTEIN 1 (PIR1) as a crucial plant-specific regulator, balancing the unfolded protein response (UPR) and ubiquitin-proteasome system (UPS) by modulating ABI5 stability, unveiling intricate stress response connections.

Tetra S-confused porphyrinoids.

Maximum confusion in porphyrinoids can be achieved by inter-linking heterocycles only through 2,4-connectivity. 20π confused porphycene and 30π expanded porphycene represent examples with the highest number of confused heterocyclic units in a given macrocycle. They significantly differ from the parent 20π porphycene and 30π hexaphyrin in their structural, electronic and redox properties due to the cross conjugation arising from the 2,4-connectivity of the heterocycle.

Topological Diversity in Electrochemically Active Core-Modified Expanded Porphyrinoids.

Thiophene-based expanded porphyrinoids undergo a transition from a planar conformation to a twisted conformation upon a systematic increase in the number of thiophene units. Octaphyrin, with 40π electrons, displayed temperature-dependent interconversion between planar and nonplanar conformations in the solution state, in contrast to the rigid planar conformation in the solid state. 60π-dodecaphyrin and 70π-tetradecaphyrin have the maximum number of π-electrons for 12- and 14-heterocycle porphyrinoids, respectively.

Serotonin: A frontline player in plant growth and stress responses.

Serotonin is a well-studied pineal hormone that functions as a neurotransmitter in mammals and is found in varying amounts in diverse plant species. By modulating gene and phytohormonal crosstalk, serotonin has a significant role in plant growth and stress response, including root, shoot, flowering, morphogenesis, and adaptability responses to numerous environmental signals. Despite its prevalence and importance in plant growth and development, its molecular action, regulation and signalling processes remain unknown.

Leaning induced layer undulated tilted smectic phase of asymmetric bent-core liquid crystals.

We report the synthesis and experimental studies on the liquid crystalline phase of a homologous series of compounds comprised of strongly asymmetric bent-core banana shaped molecules. Our x-ray diffraction studies clearly indicate that the compounds exhibit a frustrated tilted smectic phase with layer undulated structure. The low value of the dielectric constant as well as switching current measurements indicate the absence of polarization in this layer undulated phase.

AUR1 and its pals: orchestration of intracellular rhizobia infection in legume for nitrogen fixation.

We highlight the newly emerged regulatory role of a mitotic kinase AUR1, its activator, and its microtubule-associated proteins (MAPs) in infection thread formation for root nodule symbiosis.

Combinatorial delivery of CPI444 and vatalanib loaded on PEGylated graphene oxide as an effective nanoformulation to target glioblastoma multiforme: evaluation.

Glioblastoma multiforme (GBM) is known as the primary malignant and most devastating form of tumor found in the central nervous system of the adult population. The active pharmaceutical component in current chemotherapy regimens is mostly hydrophobic and poorly water-soluble, which hampers clinical implications. Nanodrug formulations using nanocarriers loaded with such drugs assisted in water dispersibility, improved cellular permeability, and drug efficacy at a low dose, thus adding to the overall practical value.

Dendrimer-Functionalized Nanodiamonds as Safe and Efficient Drug Carriers for Cancer Therapy: Nucleus Penetrating Nanoparticles.

Nanodiamonds (NDs) are increasingly being assessed as potential candidates for drug delivery in cancer cells and they hold great promise in overcoming the side effects of traditional chemotherapeutics. In the current work, carboxylic acid functionalized nanodiamonds (ND-COOH) were covalently modified with poly(amidoamine) dendrimer (PAMAM) to form amine-terminated nanodiamonds (NP). Unlike ND-COOH, the chemically modified nanodiamond platform NP revealed a pH-independent aqueous dispersion stability, enhancing its potential as an effective carrier.

Identification and analysis of miRNAs-lncRNAs-mRNAs modules involved in stem-elongation of deepwater rice (Oryza sativa L.).

Deepwater is an abiotic stress that limits rice cultivation worldwide due to recurrent floods. The miRNAs and lncRNAs are two non-coding RNAs emerging as major regulators of gene expressions under different abiotic stresses. However, the regulation of these two non-coding RNAs under deepwater stress in rice is still unexplored.

Post-symptomatic detection of COVID-2019 grade based mediative fuzzy projection.

The concept of fuzzy set, intuitionistic set, and mediative fuzzy set as a generalization of a crisp set have been introduced in many real-life applications. The concept of crisp relation between elements of sets can be extended to fuzzy relations. Extended relations will be considered as relations on fuzzy sets.

A unique miR775-GALT9 module regulates leaf senescence in Arabidopsis during post-submergence recovery by modulating ethylene and the abscisic acid pathway.

The submergence-induced hypoxic condition negatively affects the plant growth and development, and causes early onset of senescence. Hypoxia alters the expression of a number of microRNAs (miRNAs). However, the molecular function of submergence stress-induced miRNAs in physiological or developmental changes and recovery remains poorly understood.

Mediative fuzzy logic mathematical model: A contradictory management prediction in COVID-19 pandemic.

This paper presents a model based on mediative fuzzy logic in this COVID-19 pandemic. COVID-19 (novel coronavirus respiratory disease) has become a pandemic now and the whole world has been affected by this disease. Different methodologies and many prediction techniques based on various models have been developed so far.

Mathematical analysis of a within-host model of SARS-CoV-2.

In this paper, we have mathematically analyzed a within-host model of SARS-CoV-2 which is used by Li et al. in the paper published in (Math. Biosci.

Effectiveness of lock down to curtail the spread of corona virus: A mathematical model.

In this paper, we have considered a mathematical model that deals with the effectiveness of the measures that may be helpful for reducing the spread of the COVID-19 virus in the society. Here we have illustrated the importance of lock down in controlling and maintaining the spread of the COVID-19 virus. The impact of the virus on the susceptible population has been considered in the model.

Amalgamation of PI3K and EZH2 blockade synergistically regulates invasion and angiogenesis: combination therapy for glioblastoma multiforme.

Glioblastoma multiforme is known as the primary malignant and most devastating form of tumor in central nervous system of adult population. Amongst all CNS cancers, Glioblastoma multiforme GBM is a rare grade IV astrocytoma and it has the worst prognosis initiated by metastasis to supra-tentorial region of the brain. Current options for the treatment include surgery, radiation therapy and chemotherapy.

Publisher Correction: Design and efficient synthesis of pyrazoline and isoxazole bridged indole C-glycoside hybrids as potential anticancer agents.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Design and efficient synthesis of pyrazoline and isoxazole bridged indole C-glycoside hybrids as potential anticancer agents.

C-glycosides are important class of molecules exhibit diverse biological activities and present as structural motif in many natural products. Two series of new pyrazoline and isoxazole bridged indole C-glycoside molecular hybrids (n = 36) were efficiently synthesized starting from diverse indole 3-carboxaldehydes derived α, β-unsaturated ketone derivatives of β-D-glucosyl-propan-2-one, β-D-galactosyl-propan-2-one and β-D-mannosyl-propan-2-one, reacting with hydrazine hydrate and hydroxyl amine hydrochloride in shorter reaction time (15 min) under microwave assisted condition. Anticancer activity of these newly synthesized pyrazoline and isoxazole bridged indoles C-glycoside hybrids were determined in details through cellular assays against MCF-7, MDA-MB-453 and MDA-MB-231 cancer cell lines.

The H1047R PIK3CA oncogene induces a senescence-like state, pleiotropy and acute HSP90 dependency in HER2+ mammary epithelial cells.

In pre-clinical models, co-existence of Human Epidermal Growth Factor Receptor-2 (HER2)-amplification and PI3K catalytic subunit (PIK3CA) mutations results in aggressive, anti-HER2 therapy-resistant breast tumors. This is not always reflected in clinical setting. We speculated that the complex interaction between the HER2 and PIK3CA oncogenes is responsible for such inconsistency.

Adaptation to chronic exposure to sepantronium bromide (YM155), a prototypical survivin suppressant is due to persistent DNA damage-response in breast cancer cells.

Sepantronium bromide (YM155), originally developed against the anti-apoptotic protein survivin, performed exceptionally well in pre-clinical and phase I clinical trials. However, in phase II trials of several cancer types including breast cancer it performed poorly. Additionally, no definitive correlation between survivin level and response to therapy was found.

Plant small RNAs: advancement in the understanding of biogenesis and role in plant development.

Present review addresses the advances made in the understanding of biogenesis of plant small RNAs and their role in plant development. We discuss the elaborate role of microRNAs (miRNAs) and trans-acting small interfering RNAs (ta-siRNAs) in various aspects of plant growth and development and highlight relevance of small RNA mobility. Small non-coding RNAs regulate various aspects of plant development.