Study on the Genus (Caryophyllaceae)-A New Species from North-East India.

A new species of from the Kohima District (Nagaland of North-East India) is described and illustrated based on both molecular data (the ITS region of nuclear DNA) and morphometric analyses (clustering, PCA, DA, and MANOVA). The new species resembles cordata but differs with respect to the shape of the sepal (oblong, incurved at the margin vs. lanceolate, not incurved at the margin), petals (oblong or linear vs.

Dynamical Embedding of Single-Channel Electroencephalogram for Artifact Subspace Reconstruction.

This study introduces a novel framework to apply the artifact subspace reconstruction (ASR) algorithm on single-channel electroencephalogram (EEG) data. ASR is known for its ability to remove artifacts like eye-blinks and movement but traditionally relies on multiple channels. Embedded ASR (E-ASR) addresses this by incorporating a dynamical embedding approach.

Functional Disability at 3 Months in Patients with Residual Limb Swelling after Snakebite Envenoming.

Limited data indicate that snakebite survivors have persistent musculoskeletal disability. We assessed the pain and functional disability at hospital discharge and after 3 months in 47 patients treated for snakebite envenoming and with at least a specified amount of local swelling at the time of hospital discharge, using the numerical pain rating scale and the Patient-Specific Functional Scale (PSFS). Russell's viper was the most common biting snake species identified.

Biofilms from poly-vinyl alcohol/palmyra root sprout with Boswellia serrata, carbon dots and anthocyanin for sensing the freshness of sardine fish.

One of the main issues that customers worldwide have is food adulteration. In commercial packages, freshness cannot always be determined visually. Here, we propose sensitive films for use in food packaging that could alter colour to indicate a change in freshness.

Exploring the macrominerals and heavy metals profile of deep-sea fishes: A pioneering study on trawl bycatch and discards in the Arabian Sea.

This study assesses macrominerals (Na, K, Ca, Mg, P) and heavy metals (As, Cd, Cr, Cu, Ni, Pb, Se, Sn, Mn, Co, Fe, and Zn) content of deep-sea fish bycatch in the Arabian Sea, offering insights into their nutritional value, toxicant levels and health implications. Variations in Ca, K, P, Mg, and Na levels across species highlight mineral diversity. Setarches guentheri has the highest Ca (7716 mg/kg ww), K (2030.

Conservative versus early surgical treatment in the management of pyogenic spondylodiscitis: a systematic review and meta-analysis.

Spondylodiscitis is the commonest spine infection, and pyogenic spondylodiscitis is the most common subtype. Whilst antibiotic therapy is the mainstay of treatment, some advocate that early surgery can improve mortality, relapse rates, and length of stay. Given that the condition carries a high mortality rate of up to 20%, the most effective treatment must be identified.

Correlating W-Boson Mass Shift with Muon g-2 in the Two Higgs Doublet Model.

We show an interesting correlation between the recent high precision measurement of the W-boson mass by the CDF Collaboration and the muon (g-2) anomaly in the context of the two Higgs doublet model. One-loop diagrams involving the exchange of neutral scalar bosons can explain the muon (g-2), which, however, requires significant mass splittings among members of the second Higgs doublet. These splittings also generate a positive shift in the mass of the W boson, consistent with the recent CDF measurement.

Minimal Realization of Light Thermal Dark Matter.

We propose a minimal UV-complete model for kinematically forbidden dark matter (DM) leading to a sub-GeV thermal relic. Our crucial realization is that the two-Higgs-doublet model can provide a light mediator through which the DM can annihilate into standard model leptons, avoiding indirect detection constraints. The DM mass is predicted to be very close to the mass of the leptons, which can potentially be identified from DM annihilation into gamma rays.

Sardine oil loaded vanillic acid grafted chitosan microparticles improves the in vivo antioxidant, haematological and lipid profile.

Unlabelled: Oxidative stability of fish oil supplements poses a considerable health risk which can be prevented by novel delivery systems. A newly developed formulation of microencapsulated sardine oil showed excellent oxidative stability in vitro. The present study's objective is to evaluate the new formulation in vivo as a potential new supplement which may improve antioxidant, haematological, and lipid profile.

A rare case of collision tumour of the ovary complicated by torsion.

Collision tumour is the coexistence of two adjacent, but histologically distinct tumours without histologic admixture. Collision tumours are rare in the ovary. It is mostly a histopathological diagnosis often missed in preoperative imaging.

Role of Imaging in a Case of Toxoplasmosis Presenting as Generalized Lymphadenopathy.

Toxoplasmosis is caused by an obligate protozoan intracellular parasite. The disease has variable prevalence globally and is usually asymptomatic. Pregnant and immunocompromised people are at risk of getting infected.

A Druglike Small Molecule that Targets r(CCUG) Repeats in Myotonic Dystrophy Type 2 Facilitates Degradation by RNA Quality Control Pathways.

Myotonic dystrophy type 2 (DM2) is one of >40 microsatellite disorders caused by RNA repeat expansions. The DM2 repeat expansion, r(CCUG) (where "exp" denotes expanded repeating nucleotides), is harbored in intron 1 of the CCHC-type zinc finger nucleic acid binding protein (CNBP). The expanded RNA repeat causes disease by a gain-of-function mechanism, sequestering various RNA-binding proteins including the pre-mRNA splicing regulator MBNL1.

Macromineral and heavy metal profiles of selected deep-sea fish from the Kochi coast of the Arabian Sea, India.

Deep-sea fish from the Arabian Sea in the south western coast of India have been gaining attention as a new edible fish source. Mineral profile of ten selected deep-sea fish from the south west coast of India were assessed for heavy metal and macro mineral content for safety and nutritional quality assessment, respectively. Heavy metal levels were below permissible limits for most of the species studied.

The effect of temperature on water desalination through two-dimensional nanopores.

Two-dimensional (2D) materials such as graphene, molybdenum sulfide, and hexagonal boron nitride are widely studied for separation applications such as water desalination. Desalination across such 2D nanoporous membranes is largely influenced by the bulk transport properties of water, which are, in turn, sensitive to the operating temperature. However, there have been no studies on the effect of temperature on desalination through 2D nanopores.

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.

Many proteins are refractory to targeting because they lack small-molecule binding pockets. An alternative to drugging these proteins directly is to target the messenger (m)RNA that encodes them, thereby reducing protein levels. We describe such an approach for the difficult-to-target protein α-synuclein encoded by the gene.

Authentication of Two Bio-Active Fish Oils by Qualitative Lipid Profiling Using Semi-Targeted Approach: An Exploratory Study.

Background: Fish oils, which are rich in health-promoting polyunsaturated fatty acids (PUFA), have emerged as promising functional foods in the global health and wellness food market. Their source regarding the fish type, season, and location of harvesting might influence the nutritional value of such bioactive oils and determine their market price. The differences in price among such oils often lead to economically motivated mislabeling and adulteration.

Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA.

Small-molecule targeted recruitment of nucleases to RNA is a powerful method to affect RNA biology. Inforna, a sequence-based design approach to target RNA, enables the design of small molecules that bind to and cleave RNA in a selective and substoichiometric manner. Here, we investigate the ability of RNA-targeted degradation to improve the selectivity of small molecules targeting RNA.

Chitosan - Whey protein as efficient delivery system for squalene: Characterization and functional food application.

Squalene, a triterpenoid compound possessing excellent bioactivities, is not being utilized as a functional food ingredient due to its high susceptibility to oxidation. In the present study, the feasibility of chitosan-whey protein as an efficient wall material for squalene encapsulation using spray drying technique was attempted for functional food applications. The encapsulation efficiency of the squalene powder was found to be 75.

Water flow in carbon nanotubes: the role of tube chirality.

We investigated the effects of the chirality of carbon nanotubes (CNTs) on water transport using molecular dynamics simulations. For the study, we considered CNTs with similar diameter and varying chiralities, obtained by altering the chiral indices (n,m) of the nanotubes. The tubes with an armchair (n = m) structure show the maximum streaming velocity, flux, flow rate enhancement and slip length, whereas the corresponding values are lower for chiral (n≠m) tubes, and are the lowest in zigzag (m = 0) CNTs.

Proteoglycans isolated from the bramble shark cartilage show potential anti-osteoarthritic properties.

Osteoarthritis (OA) causes articular cartilage destruction, initiating pain and inflammation in the joints, resulting in joint disability. Medications are available to manage these symptoms; however, their effects on the disease progression are limited. Loss of proteoglycans (PGs) was reported to contribute articular cartilage destruction in OA.