[Epinephros metastasis of colorectal cancer complicated by tumor thrombosis of inferior vena cava].

Metastasis of colorectal cancer (CRC) in an adrenal gland develops in 1.8% of cases (in synchrony or in metachrony) for patients with liver metastatic lesion and aggravates for certain prognosis for long-term survival. There are no data concerning colorectal metastasis in an adrenal gland with tumor thrombosis of inferior vena cava (IVC) in world-wide literature.

[Medical and biologic research of electromagnetic fields in radiofrequencies range. Results and prospects].

The authors present research findings on the problem of technology-related electromagnetic fields as an occupational risk factor of workers health disturbances, and on the issue of prevention measures development against this adverse physical factor effects. Prospects for further research development in the field of electromagnetic safety are discussed.

[Ian Vladimirovich Bokhman and the St. Petersburg School of Oncogynecology].

The article describes the history of the formation of the St. Petersburg school of oncogynecology based at the Department of Oncogynecology of the N. N.

[Phospholipids and structural modification of tissues and cell membranes for adaptation in high altitude mountains].

The nature of the impact of physical factors of high altitudes (3200 m) on the lipids of tissues and membranes of animals was researched. It was established that the adaptation process in Wistar rats was followed by peroxide degradation and subsequent modification of the phospholipids' structure of tissues and microsomal membranes. Adaptive phospholipids reconstruction takes place in microsomal membranes in the tissues of the lungs, brain, liver and skeletal muscles.

[The diagnostic value of RNA oncomarkers in evaluation of malignant breast tumors].

The levels of the RNA oncomarkers, telomerase (hTERT), cytokeratin-19 (CK-19) and mammaglobin (MAM) have been investigated in capillary blood of female patients with mammary ductal carcinoma. The study revealed overexpression of all three factors in patients with this pathology. This overexpression was not found in healthy donors and female patients with mammary fibroadenoma.

[Sternal osteosynthesis after cardiac surgery].

Sternal fixation with nickelide titanium staples with shape memory effect is considered to be a novel method of wound closure after cardiac operations. The study includes data of 140 patients and is devoted to the preliminary assessment of the use of the mentioned fixators with self-regulating compression. Osteosynthesis proved to be completely effective in 136 (97,1%) patients.

[Oxidative homeostasis and functional parameters of rats at high altitudes with alpha-lipoic acid correction].

Oxidative and functional effects of alpha-lipoic acid (a-LA) were studied in the course of 45-day adaptation to high altitudes (3200 m in the Central Tien Shan, June - August). Comparison of a-LA with mildronate stated similarity of their antioxidant and membrane effects on the third (stable) phase of adaptation (day 45), as both substances demonstrated a distinct lyso-PL-limiting effect and did not change dramatically concentration of diene conjugates (primary products of lipid peroxidation) in brain tissue. a-LA surpassed mildronate in the rate of the compensating effect in respect of behavior disorders and anxiety in rats.

[Prediction of left ventricular remodeling after acute myocardial infarction].

Prediction of adverse left ventricular remodeling after acute myocardial infarction (AMI) may have important clinical implications. In this study, we evaluated the incidence of unfavorable changes of left ventricular volumes and ejection fraction after AMI. The ability of several cardiac markers, electrocardiographic and echocardiographic (including tissue Doppler) variables to predict adverse remodeling was demonstrated.

[Cardiac electrode as a cause of the chronic sternal ostheomyelitis].

Results of the diagnostic concept and treatment of 5 patients with the chronic sternal ostheomyelitis after the open cardiac surgery caused by the "forgotten" cardiac electrodes were analyzed in the article. The radiologic diagnostic criteria and necessity of the computed tomography, in particular, were stated.

[Membrane and functional effects of vinpocetine and tocopherol in rats with experimental cerebral ischemia].

The membrane, antioxidant and functional effects of vinpocetine and a-tocopherol have been investigated under conditions of acute experimental cerebral ischemia in rats. Vinpocetine administration decreased accumulation of lysophospholipids in brain plasma membranes. Vinpocetine also blocked accumulation of conjugated dienes (CD).

[Specific complaints and pain syndrome in nonspecific osteomyelitis of the spine].

The complaints were studied and pain syndrome estimated in 125 patients with nonspecific osteomyelitis of the spine (NOS). Complex conservative treatment was given to 74 of the patients, on 51 patients radical-restorative operations on the spine were fulfilled. The investigation has revealed specific features of pain syndrome in acute and chronic forms of NOS, in operative and conservative treatment.

[Decision on the immunomodulating therapy in unspecific osteomyelitis of the spine].

Immunomodulating therapy was used in treatment of 54 patients with unspecific osteomyelitis of the spine (UOS). The age of the patients was from 15 through 76 years. The authors consider that immunocorrection should be included in the complex of obligatory measures of treatment of patients with purulent infections of the spine and is dependent on the type of immunological impairments.

[Experimental study of magnetic field influence on transitory instability of display image].

The article presents results of experimental study that determined threshold level of external magnetic field causing no flashing effect and spectral distribution of image instability, if general and local influence of magnetic field on display.

Parameters of cell energy metabolism during stress in laboratory animals and energotropic effect of alpha1-adrenoblocker doxazosin.

Cytochemical activity of succinate dehydrogenase and lactate dehydrogenase in blood lymphocytes, activity of hydroperoxides, MDA, and blood plasma antioxidants were studied in experimental animals during immobilization stress after preliminary injection of doxazosin. Preliminary adrenergic receptor blockade prevented changes in cell metabolism characteristic of immobilization stress. The role of adrenergic regulation in the realization of energotropic effects during immobilization stress was examined.

[Assessment of the immuological status in patients with nonspecific spinal osteomyelitis].

The authors describe results of the investigation of the immunological status of 54 patients with nonspecific osteomyelitis of the spine (NOS). The immunological status of NOS patients was shown to be substantially different in the acute and chronic phases of the disease. Cases with lower T-lymphocyte activity, with a dysfunction of the phagocytic activity of lymphocytes prevail in the acute phase.

[Viagra effects on polysystemic energy metabolism in stress (an experimental study)].

Experiments on 40 white rats were made to study effects of cardura (doxasozine) and viagra on polysystemic energy metabolism in stress. All the animals were examined for cytochemical activity of succinate dehydrogenase, lactate dehydrogenase in blood lymphocytes, antioxidant activity of blood plasm, levels of hydroperoxides, malonic dialdehyde. 3-hour immobilization raises functional activity of mitochondria manifesting with intensification of energy metabolism.

[Activity of the messenger systems in the altitude chamber hypoxia].

The activity of phosphoinositide and adenylate cyclase systems of second messengers in rat brain were investigated under altitude chamber treatment (6000 m x 24 hours). Selective suppression of each messenger system was achieved by pretreatment of rats with either lithium chloride or propranolol for 8 days. Consequences of this treatment and/or hypoxia were evaluated by orientation behavior and physical exercise test.

Study of total lipid peroxidation and antioxidant activity in pulmonary and mediastinal malignant and benign tumor tissue.

Total lipid peroxidation and antioxidant activity were studied in pulmonary and mediastinal malignant and benign neoplasms. In malignant tumors total lipid peroxidation increased and antioxidant activity decreased; the intensity of these shifts depended on histological characteristics and degree of malignancy: the most pronounced changes were observed in thymoma and adenocarcinoma tissues and minimum changes were found in bronchoalveolar carcinoma tissue.

[The study of the antioxidant enzymes in erythrocytes in lung diseases].

The activity of antioxidative enzymes Cu, Zn-superoxidedismutase (SOD) and catalase as well as content of glutathione and activity of its metabolism enzymes--glutathione reductase (GR) and glutathione peroxidase (GP) were studied in red blood cells of 82 patients: with chronic obstructive pulmonary diseases (COPD, n = 26), chest osteomyelitis (n = 12), malignant (n = 21) and benign (n = 23) pulmonary lesions. Red blood cells from 26 donors served as a control. Enzymes of glutathione and catalase metabolism in the red cells inhibited their activity in all the above pulmonary diseases vs those of the controls: GR activity in COPD and chest osteomyelitis decreased by 40% and more, lung tumors--by 32-36%.

[Evaluation of the capacities of neurophysiological intraoperative monitoring in reconstructive surgery on the vertebral column].

Aim: To evaluate the capacities of neurosurgical intraoperative monitoring of somatosensory evoked potentials (SSEP) in reconstructive operations on the vertebral column.

Materials And Methods: The Center of Spinal Surgery examined 30 patients treated in February to July 2001. According to the diagnosis, the distribution was as follows: degenerative diseases of the vertebral column (80%), its tumors (10%), injury (7%), and inflammatory diseases (3%).

Effect of panangin on activity of messengers systems in hypertrophied rat myocardium.

The balance between the two major second messenger systems in hypertrophied myocardium was studied in rats receiving panangin for 16 days. Panangin producing stimulating and polarizing effects on cardiomyocyte membrane improved electrophysiological characteristics of hypertrophied myocardium (electrical stability, duration of supernormal excitability period, and action potential), activated the phosphoinositide exchange, and inhibited the adenylate cyclase system. The panangin-induced change in membrane potentials was accompanied by a pronounced inositol response, i.