Novel pyrimido-pyridazine derivatives: design, synthesis, anticancer evaluation and studies.

A novel pyrimido-pyridazine derivative for developing anticancer agents was synthesized via Ullmann arylation using an efficient Cu(OAc) catalyst. Compounds were investigated for their anticancer potential, against human breast adenocarcinoma cells, viz. MCF-7, MDA-MB-231 and normal cell line HEK-293.

Sodium sulphide promoted synthesis of fused quinoline at room temperature.

A novel, simple and eco-friendly strategy for the synthesis of thiopyrano[4,3-]quinolin-1-ones and pyrrolo[3,4-]quinolin-1-ones from 2-alkynylquinoline-3-carbonitriles and sodium sulphide (NaS·9HO) under catalyst-free conditions at room temperature has been described. In this reaction, a readily available inorganic salt (NaS·9HO) serves as the sulphur source and leads to the generation of diverse functionalized thiopyrano[4,3-]quinolin-1-ones and pyrrolo[3,4-]quinolin-1-ones in moderate to excellent yields through sulfuration, annulation, and aerial oxidation.