Publications by authors named "Vishal Basu"
Cell Commun Signal
September 2024
Article Synopsis
- Mitochondria-targeting agents, or mitocans, are becoming promising cancer treatments due to their effects on cancer cell metabolism and apoptosis, with ONC212 being a key compound studied.
- Despite ONC212 showing effectiveness in inducing cell death in cancer cells like HeLa and A549, its specific mechanisms are still not fully understood.
- The study reveals that ONC212 triggers apoptotic features without typical mitochondrial changes and can enhance cell death when combined with a Bcl-2/Bcl-xL inhibitor, indicating its potential for use in combination therapies for tumors with impaired mitochondrial signaling.
