Influence of outer membrane permeabilization on intrinsic resistance to the hydrophobic biocide triclosan in opportunistic species.

Triclosan is a hydrophobic antimicrobial agent commonly employed in health care settings. While it exhibits broad-spectrum antibacterial properties, the gram-negative nosocomial opportunists and are atypically refractory. Intrinsic resistance to triclosan in is largely due to its outer membrane impermeability properties for hydrophobic and bulky substances.

Perceived Age and Personality Profiling after Orthognathic Surgery.

Background: Recent studies suggest that orthognathic surgery can improve facial age and personality profiling. The authors expand on these findings by assessing the role of patient facial profile and sociodemographics on perceived changes following surgery.

Methods: Preoperative and postoperative images of 65 patients operated on by a single surgeon were randomly assorted and rated by 30 respondents.

Immunogenicity of biologics used in the treatment of moderate to severe psoriasis.

The number of biologic drugs available for the treatment of psoriasis continue to expand. However, being biological proteins and thus potentially immunogenic, there is evidence that anti-drug-antibodies develop against the various therapeutic proteins currently being utilised. Although chimeric antibodies that contain elements of the parental rodent monoclonal antibodies are immunogenic, anti-drug antibodies occur even if the biologic is a fully human protein and these can impact on clinical efficacy and safety.

Cargo transport shapes the spatial organization of a microbial community.

The human microbiome is an assemblage of diverse bacteria that interact with one another to form communities. Bacteria in a given community are arranged in a 3D matrix with many degrees of freedom. Snapshots of the community display well-defined structures, but the steps required for their assembly are not understood.