Influence of outer membrane permeabilization on intrinsic resistance to the hydrophobic biocide triclosan in opportunistic species.

Triclosan is a hydrophobic antimicrobial agent commonly employed in health care settings. While it exhibits broad-spectrum antibacterial properties, the gram-negative nosocomial opportunists and are atypically refractory. Intrinsic resistance to triclosan in is largely due to its outer membrane impermeability properties for hydrophobic and bulky substances.