Abdominal perfusion pressure and coronary arterial perfusion pressure in patients undergoing coronary artery bypass graft surgery.

Abdominal perfusion pressure (APP) is defined as the difference between the mean arterial pressure and the intra-abdominal pressure (IAP). IAP elevation results in various side effects, including a decrease in coronary arterial perfusion pressure (CoPP). The present study analyzed the relationship between APP and CoPP in patients undergoing extracorporeal circulation (ECC).

The efficiency of magnesium supplementation in patients undergoing cardiopulmonary bypass: changes in serum magnesium concentrations and atrial fibrillation episodes.

Unlabelled: The purpose of the study was to analyse the effects of different forms of magnesium supplementation on its serum concentrations and the frequency of atrial fibrillation in patients undergoing coronary artery bypass graft surgery with extracorporeal circulation (ECC). One hundred and twenty adult patients were examined. All of them received intravenous infusions of MgSO4 during surgery and the early postoperative period (18 hours).

Chlamydia trachomatis and herpes simplex virus 2 infection in vulvar intraepithelial neoplasia associated with human papillomavirus.

Background: The role of viral and bacterial co-infection is stressed in VIN. A view that VIN is a sexually transmitted disease made the area of research larger and stimulated scientists to seek other sexually transmitted factors, among which Chlamydia trachomatis and Herpes simplex are frequently examined.

Purpose: The aim of the study was to evaluate the frequency of occurrence of HPV DNA and the frequency of co-infection with Herpes virus type 2 and Chlamydia trachomatis in VIN.

Investigations of ultrastructure of damaged and regenerated skeletal muscle fibers.

Our investigations concerned the head of the parietal part of quadriceps femoris, and we based our investigation on observations of the ultrastructure of muscle fibers using an electron microscope. We observed tissue samples taken from patients (10 men) 25-35 years old, who had old damage of knee joint ligament (after about 6 week's immobilization). In the first group, segments of tissue of parietal head of quadriceps femoris were taken inter-operationally from patients in whom there was found old damage of knee joint ligament.

Histological examination of the kidney after experimental administration of MK-801 and dexamethasone.

The aim of the research was histological assessment of the influence of MK-801 (NMDA receptor antagonist) and dexamethasone on the kidney. The experiment was carried out on adult Albino-Swiss mouse males. MK-801 was administered in the dose of 0.

Histomorphology of renal proximal convoluted tubules of kidney of experimental animals after Cladribine (2-CdA) administration.

The proximal convoluted tubules of the kidney of the white Wistar rats were examined. The animals were given Cladribine (2-CdA) sub-cutaneously at the dose: 0.07 mg/kg b.

Histomorphology of renal corpuscles of kidney of experimental animals after Cladribine (2-CdA) administration.

The renal corpuscles of the kidney of white Wistar rats was examined. The animals were given Cladribine (2-CdA) subcutaneously at the dosages of 0.07 mg/kg b.

Histological and morphometrical examinations of suprarenal glands in rats after experimental administration of atorvastatin and ethanol.

The experiment was carried out on Wistar rat males weighting about 250 g. Animals from control group I received water and standard granulated fodder ad libitum. Animals from control group II received 20% ethanol instead of water.

Ultrastructural changes of pancreas of white rats after experimental administration of ethanol and cephalexin.

The experiment was carried out on Wistar rat males weighting about 200 g. Animals from experimental group I received 20% ethanol for drinking (ad libitum), animals from experimental group II--cephalexin in the dose of 42 mg/24 h, animals from experimental group III--cephalexin and ethanol in the mentioned doses. After 10 days the animals were decapitated and pancreases were collected for ultrastructural examinations in electron microscope.

The influence of Atorvastatin on ultrastructure of rat pancreatic exocrine cells in the course of experimental intoxication with ethanol.

The experiment was carried out on mature Wistar male rats. The animals from experimental group I received Atorvastatin in the dose 0.28 mg/24 h for 3 weeks.

Histological changes in the pancreas of white rats after administering cephalexin and ethanol.

The research was conducted on male Wistar rats weighing approximately 200 g. Animals of experimental group I were administered 20% ethyl alcohol for drinking, animals of experimental group II--cephalexin in the dose of 42 mg daily, animals of experimental group III--simultaneously alcohol and cephalexin in the mentioned doses. After 10 days the animals were guillotined and pancreas was taken for research.

Neuroprotective effect of ACTH (4-9) in degeneration of hippocampal nerve cells caused by dexamethasone: morphological studies.

The purpose of this research was an assessment of neuroprotective effect of ACTH (4-9) in degenerative changes of nerve cells induced by dexamethasone. Experiments were led on Albino-Swiss mouse males. We examine morphological changes of neurons in the dorsal hippocampus in slides stained with cresyl violet and we performed quantitative analysis of neurodegenerative changes using a computer analyser of histological pictures.

Immunocytochemical examinations of hippocampal nerve cells after experimental administration of dexamethasone.

The purpose of this research was an assessment of MAP2 immunoreactivity in hippocampal neurons after administration of toxic doses of dexamethasone. Experiments were led on Albino-Swiss mouse males. The obtained results indicate that dexamethasone causes significant decrease of MAP2 immunoreactivity in hippocampal nerve cells of the CA3 region.

Protective effects of ACTH (4-9) in degeneration of hippocampal nerve cells caused by dexamethasone: ultrastructural studies.

The purpose of this research was an assessment of protective action of ACTH (4-9) in dexamethasone-induced neurodegeneneration on the base of ultrastructural examinations of hippocampal neurons in the CA3 region. The experiments were carried out on adult Albino Swiss mouse males. The animals were divided into three groups: control group, experimental group 1-dexamethasone 8 mg/kg/24 h for 28 days, experimental group 2-dexamethasone and ACTH (4-9) 50 micrograms/kg twice a week.

Influence of the new medicine--2-CDA (Cladribine) on the ultrastructure of the extrabulbar segment of the optic nerve in rabbits of New Zealand breed.

Experiments were carried out on the rabbits of New Zealand breed weighting about 3 kg. Rabbits from the experimental group received Cladribine in the dose of 0.07 mg/kg/24 h each morning subcutaneously for 6 days, three cycles with 5-week intervals.

Histological examination of the extrabulbar segment of the optic nerve in experimental animals after administration of Cladribine.

The experiment was carried out on rabbits, females of New Zealand breed, weighting about 3 kg. Rabbits from the experimental group I received Cladribine in the dose corresponding to the schema of the experimental treatment in the hairy cell leukemia and animals from the experimental group II, the dose corresponding to the experimental treatment in multiple sclerosis. The optic nerves were collected for histological examinations in the light microscope.

Intrapleural alteplase in a patient with complicated pleural effusion.

Objective: To report the intrapleural use of alteplase in a patient diagnosed with complicated pleural effusion (CPE).

Case Summary: A 62-year-old white woman admitted with respiratory distress and hypotension developed a right-sided multi-loculated pleural effusion. Thoracentesis and chest tube drainage were not successful in resolving the effusion.

Phase I dose escalation study of topotecan combined with alternating schedules of paclitaxel and carboplatin in advanced solid tumors.

Background: Combining topotecan with other cytotoxics has been problematic due to marrow suppression. A phase I trial was initiated to identify the optimal sequence and maximum-tolerated dose of topotecan in combination with paclitaxel and carboplatin.

Patients And Methods: Patients with advanced cancer and performance status ECOG < or = 2.

Blastic variant of mantle cell lymphoma following interfollicular Hodgkin's lymphoma.

Infrequently, patients are diagnosed with Hodgkin's lymphoma and a morphologically distinct lymphoma. While specific subtypes of lymphomas (including Hodgkin's lymphoma) may present diagnostic difficulties, fine needle aspiration biopsy (FNAB) is sometimes useful in the evaluation and classification of these lymphoproliferative processes. We report a case of the blastic variant of mantle cell lymphoma following Hodgkin's lymphoma, interfollicular variant.

Cerebral mucormycosis: proton MR spectroscopy and MR imaging.

Proton magnetic resonance spectroscopy (MRS) was integrated with magnetic resonance imaging (MRI) in the evaluation of a case of cerebral mucormycosis. MRS showed markedly elevated lactate, depleted N-acetyl aspartate and metabolite resonances attributable to succinate and acetate. The spectroscopy profile is essentially similar to that of bacterial abscess but without the commonly seen resonances of the amino acids valine, leucine and isoleucine.

Angiotensin II receptor blockers in patients with ACE inhibitor-induced angioedema.

Objective: To determine the safety of using angiotensin II receptor blockers in patients who have experienced angioedema following treatment with angiotensin-converting enzyme (ACE) inhibitors.

Data Sources: Clinical literature identified through MEDLINE (January 1966-August 1999). Key search terms included angioneurotic edema, angiotensin-converting enzyme inhibitors, receptors-angiotensin, and losartan.

Flow cytometric immunophenotyping of bone marrow core biopsies: report of 8 patients with previously undiagnosed hematologic malignancy and failed bone marrow aspiration.

Objective: To report a method for flow cytometric immunophenotyping (FCI) bone marrow (BM) core biopsies in patients with hematologic malignancies of the BM who present with a failed BM aspiration ("dry tap").

Design And Setting: Core biopsy specimens of BM were obtained from 8 patients who presented with previously undiagnosed hematologic malignancies arising in (7 cases) or secondarily involving (1 case) the BM and a dry tap. Suspensions of the BM core biopsy specimens were prepared and analyzed by FCI methods.