Publications by authors named "Virpi Stigzelius"
Article Synopsis
- Immunotherapy, particularly using oncolytic adenoviruses that express specific cytokines, shows potential for treating clear cell renal cell carcinoma (ccRCC).
- The study found that adenovirus treatment led to increased cytokine secretion and significant T-cell migration toward treated tumor cells, highlighting the role of CXCR3 receptors on T-cells, especially CD8+ T-cells.
- Additionally, the research identifies immunogenic antigens that could improve the effectiveness of adenoviral treatments and emphasizes the importance of patient-derived organoids for developing and validating new immunotherapy strategies.
Background: Cancer immunotherapy relies on using the immune system to recognize and eradicate cancer cells. Adaptive immunity, which consists of mainly antigen-specific cytotoxic T cells, plays a pivotal role in controlling cancer progression. However, innate immunity is a necessary component of the cancer immune response to support an immunomodulatory state, enabling T-cell immunosurveillance.
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