Publications by authors named "Virly N Muzellina"
The lack of clear definition and classification for "moderate ulcerative colitis (UC)" creates ambiguity regarding the suitability of step-up versus top-down treatment approaches. In this paper, experts address crucial gaps in assessing and managing moderate UC. The Asia-Pacific, Middle East, and Africa Inflammatory Bowel Disease Coalition comprised 24 experts who convened to share, discuss and vote electronically on management recommendations for moderate UC.
View Article and Find Full Text PDFArticle Synopsis
- Colonoscopy is a generally safe procedure, but some patients experience gastrointestinal issues afterward; this study explored whether probiotics can help mitigate these symptoms before and after the procedure.
- Ten studies were analyzed, with findings showing that probiotics did not significantly impact symptoms like bloating or abdominal pain either before or after colonoscopy.
- Though the results suggest probiotics might help reduce gastrointestinal discomfort, the overall analysis revealed non-significant results, indicating a need for more research in this area.
: Coronavirus disease 2019 (COVID-19) cases caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Indonesia remain high. The virus can bind with ACE2 receptor which is not only found in the lungs, but also in the digestive tract. Thus, it allows SARS-CoV-2 infection in the gastrointestinal tract, gastrointestinal manifestations, and detection of viral RNA on anal swab using polymerase chain reaction (PCR).
View Article and Find Full Text PDFDyspepsia still becomes a major challenge in upper gastrointestinal disease in Indonesia. This disease often correlated with Helicobacter pylori infection. However, the prevalence of this bacterium is generally low in Indonesia.
View Article and Find Full Text PDFColorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide and genetic mutation plays a vital role in CRC development. A previous study has suggested that genetic alterations among Indonesian patients with CRC might differ from those known in developed countries. This study aimed to describe the genomic profiles of Indonesian patients with CRC.
View Article and Find Full Text PDFBackground: Inflammation in chronic functional constipation (CFC) occurs systemically and has association with depressive symptoms. Biomarkers of inflammation can be assessed by the neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. These inflammation biomarkers are stable, cheap, and widely available.
View Article and Find Full Text PDFBackground: Besides biological impact, COVID-19 also poses a threat to psychological wellbeing and the quality of life. Healthcare workers, especially those assuming a front-line post, are at a higher risk of being affected, both physically and psychologically. This study aims to analyse variables potentially associated with burnout and psychological distress among healthcare workers with various health center stratifications, where we commenced a nationwide survey to establish the baseline data.
View Article and Find Full Text PDFA randomized controlled trial to evaluate the effect of influenza vaccination and probiotic supplementation on immune response and incidence of influenza-like illness in an elderly population in Indonesia.
PLoS One
January 2022
Article Synopsis
- The study aimed to analyze how influenza vaccinations and probiotic supplements affect the immune response and incidence of influenza-like illness (ILI) in elderly individuals.
- Conducted with 554 healthy elderly participants, the trial randomly assigned them to receive either the influenza vaccine or a placebo, combined with either probiotics or a placebo over six months.
- Results indicated that the influenza vaccine effectively increased protective antibody levels, while probiotics did not significantly impact antibody responses or ILI incidence, although there was a slight trend suggesting potential benefits with probiotics.
Background: An increasing trend in colorectal cancer (CRC) occurring at younger ages has been observed worldwide, even though incidence is declining in the general population. Most currently available guidelines still recommend CRC screening for older populations, despite an alarming rise in early-onset CRC incidence. Risk stratification is necessary to further determine the population most at risk for early-onset CRC.
View Article and Find Full Text PDFBackground: Researchers believe the role of gut microbiota dysbiosis in the raised incidence of early-onset colorectal cancer (EOCRC). The development of EOCRC may be associated with microbiota dysbiosis either dependently or independently (combined with other risk factors).
Summary: Recently, the rising of incidence and mortality of EOCRC have been noted.
Objective: This study will test the performance of the anal swab PCR test when compared with the nasopharyngeal swab PCR test as a diagnostic tool for COVID-19.
Design: An observational descriptive study which included hospitalised suspected, or probable cases of hopitalised COVID-19 patients, conducted in Dr. Cipto Mangunkusumo National Hospital, Ciputra Hospital, Mitra Keluarga Depok Hospital and Mitra Keluarga Kelapa Gading Hospital, Indonesia.