Publications by authors named "Viridiana Abigail Correa-Navarro"
Paternal exposure to high-fat diets or individual fatty acids (FAs) including arachidonic acid (AA) modifies progeny traits by poorly understood mechanisms. Specific male reproductive system FAs may be involved in paternal inheritance, as they can modify a range of cellular components, including the epigenome. Our objective was to determine FAs in compartments of the male reproductive system that potentially affect ejaculate composition-right and left testicular interstitial fluid (TIF), vesicular gland fluid (VGF), and epididymal adipose tissue (EAT)-in mice exposed to AA or vehicle daily for 10 days ( = 9-10/group).
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- Increasing DNA hypermethylation is linked to cardiovascular risk, prompting research on the DNA methyltransferase inhibitor decitabine (Dec) to improve metabolic health in mice on a high-animal fat and protein diet.
- Dec significantly reduced body weight gain in female mice and influenced lipid metabolism by increasing muscle lipid and plasma fatty acids while decreasing liver fat.
- Results suggest Dec enhances mitochondrial function and redirects lipid accumulation to skeletal muscle, but also causes insulin resistance in adipose tissue, highlighting potential therapeutic strategies for lipid-related metabolic issues.