Publications by authors named "Virginie Saguet-Rysanek"
Objective: 18F-Fluorocholine (18FCH) PET/CT has high sensitivity for parathyroid adenoma detection and can reliably exclude malignancy in thyroid nodules with indeterminate cytology. Data regarding 18FCH uptake in chronic autoimmune thyroiditis (CAT) are scarce. We aimed to assess thyroid 18FCH uptake in CAT with biological and histological correlation.
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- The study examined prostate-specific membrane antigen (PSMA) expression in differentiated thyroid cancer (DTC) patients with persistent/recurrent disease in the neck and its link to patient outcomes.
- A total of 44 patients were analyzed, showing that 68% had at least one PSMA-positive lesion, with higher rates in patients who were 18FDG-positive and RAI-negative.
- Strong PSMA expression was found to correlate with worse prognostic factors and shorter progression-free survival, suggesting its potential role in managing RAI-refractory DTC.
F-Fluorocholine Positron Emission Tomography/Computed Tomography is a Highly Sensitive but Poorly Specific Tool for Identifying Malignancy in Thyroid Nodules with Indeterminate Cytology: The Chocolate Study.
Thyroid
May 2021
Refining the risk of malignancy in patients presenting with thyroid nodules with indeterminate cytology (IC) is a critical challenge. We investigated the performances of F-fluorocholine (FCH) positron emission tomography/computed tomography (PET/CT) to predict malignancy. Between May 2016 and March 2019, 107 patients presenting with a thyroid nodule ≥15 mm with IC and eligible for surgery were included in this prospective study.
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- The study investigates how tumor burden in patients with differentiated thyroid cancer relates to the American Thyroid Association’s risk-stratification system and affects treatment outcomes.
- It includes 618 patients who received postoperative radioiodine therapy, categorizing tumor burden into very small, small, and large-volume persistent disease.
- Results show that larger tumor burdens correlate with higher risk levels and significantly lower response rates to therapy, highlighting the importance of tumor size in predicting treatment success.
Purpose: The aim of this prospective study (ClinicalTrials.gov: NCT01880203) was to evaluate the diagnostic and prognostic value of a 7-panel mutation testing in the aspirates of thyroid nodules with indeterminate cytology (IC).
Methods: Eligible patients had a thyroid nodule ≥15 mm with IC (Bethesda III-V) for which surgery had been recommended.
Article Synopsis
- * An ultrasound confirmed a 16-mm nodule in the right thyroid lobe, and while the serum calcitonin level was elevated, the cytology showed non-diagnostic results.
- * After a right lobectomy, the pathology confirmed a 15-mm medullary thyroid cancer, and two months post-surgery, the patient's calcitonin level returned to normal.
The genome sequence and annotation of Campylobacter coli strain IPSID-1 are reported here. This bacterial isolate is the first to be cultured from a patient with immunoproliferative small intestinal disease (IPSID). The draft genome sequence is 1.
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