Publications by authors named "Virginie Cendret"
Mannose Receptor (MR) and DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) are two mannose-specific targets for antigens carried by liposomes but DC-SIGN is more specific of DCs. Here, DC targeting is addressed by using DPPC/DOPE liposomes decorated with a series of diether lipids with a polar head of either a mannose (Man), tri-antenna of α-d-mannopyranoside (Tri-Man), [Manα1-3(Manα1-6)Man] (Man-tri), pseudo-Man (PMan) or pseudo-Man (PMan). Liposomes decorated with Man-Tri show the highest binding and internalization in cells expressing DC-SIGN and in human monocytes-derived DCs.
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- Terminal high-mannose oligosaccharides play crucial roles in various biological processes, but synthesizing them has been difficult, creating challenges in research and application.
- Multivalent structures designed to mimic these oligosaccharides have so far struggled to replicate the specific affinities for binding to natural receptors and antibodies.
- The study introduces new "click" chemistry-based high-mannose oligosaccharide mimics that closely resemble the natural structure and branching, showing similar binding affinities to important lectins, thus overcoming previous limitations.
A dendritic "click" mannooligomer mimicking the high-mannose oligosaccharide Man(8) has been designed by replacing some of the inner mannopyranosyl subunits with triazole moieties; evaluation of its binding affinity towards the mannose-specific lectin concanavalin A revealed striking similarities between the "click" mimic and the natural Man(8).
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