Publications by authors named "Virginie Begin"
Article Synopsis
- - The tumor suppressor PML plays a crucial role in regulating cellular senescence and terminal differentiation, pushing cells to permanently exit the cell cycle by activating the p53 pathway and recruiting E2F transcription factors along with retinoblastoma (Rb) proteins to specific nuclear bodies.
- - Disruption of Rb functions or reintroducing E2Fs in cells expressing PML can reverse the senescence-related defects, enhancing E2F-dependent gene expression and cell proliferation.
- - In benign prostatic hyperplasia, PML levels are increased and form nuclear bodies, unlike in prostate cancers, indicating that the identified PML/Rb/E2F pathway could help differentiate benign tumors from malignancies and highlight E2F target genes as potential
