Isometric Hamming embeddings of weighted graphs.

A mapping from the vertex set of one graph to another graph is an if the shortest path distance between any two vertices in equals the distance between their images in . Here, we consider isometric embeddings of a weighted graph into unweighted Hamming graphs, called Hamming embeddings, when satisfies the property that every edge is a shortest path between its endpoints. Using a Cartesian product decomposition of called its , we show that every Hamming embedding of may be partitioned into a , whose parts provide Hamming embeddings for each factor of the canonical isometric representation of .

Factorization and pseudofactorization of weighted graphs.

For unweighted graphs, finding isometric embeddings of a graph is closely related to decompositions of into Cartesian products of smaller graphs. When is isomorphic to a Cartesian graph product, we call the factors of this product a factorization of . When is isomorphic to an isometric subgraph of a Cartesian graph product, we call those factors a pseudofactorization of .

Barriers, facilitators and interventions to support help-seeking amongst young people living in families impacted by parental mental illness: A systematized review.

Aim: Children living in families impacted by parental mental illness are at increased risk of adverse mental and physical health outcomes compared with children living in families unaffected by mental illness. Considered to be a hard-to reach group, it is likely that there are unique barriers for these young people in seeking help for their difficulties. This systematized review synthesizes what is currently known about help-seeking barriers, facilitators and interventions for young people affected by parental mental illness.

Aiding diagnosis of childhood attention-deficit/hyperactivity disorder of the inattentive presentation: Discriminant function analysis of multi-domain measures including EEG.

Introduction: We developed a neurocognitive assessment tool (NCAT) in consultation with mental health professionals working with children with AD/HD as a diagnostic aid and screening tool. This study examines the predictive utility of NCAT in the classification of children with AD/HD Inattentive presentation.

Method: Fifty three children with AD/HD Inattentive presentation and 161 typically-developing children completed an NCAT assessment.

Stress management in the workplace for employees with hypertension: a randomized controlled trial.

While behavioral interventions can improve blood pressure (BP) in individuals with hypertension, getting such services to people who could benefit remains difficult. Workplace programs have potential as dissemination vehicles. The objective is to evaluate the effectiveness of a standardized stress management program delivered in groups at the workplace for reducing BP compared with enhanced usual care.

A 2-Year Holistic Health and Stress Intervention: Results of an RCT in Clergy.

Introduction: This study sought to determine the effect of a 2-year, multicomponent health intervention (Spirited Life) targeting metabolic syndrome and stress simultaneously.

Design: An RCT using a three-cohort multiple baseline design was conducted in 2010-2014.

Setting/participants: Participants were United Methodist clergy in North Carolina, U.

A cluster-randomised controlled trial of values-based training to promote autonomously held recovery values in mental health workers.

Background: The implementation and use of evidence-based practices is a key priority for recovery-oriented mental health service provision. Training and development programmes for employees continue to be a key method of knowledge and skill development, despite acknowledged difficulties with uptake and maintenance of behaviour change. Self-determination theory suggests that autonomy, or a sense that behaviour is self-generated, is a key motivator to sustained behaviour change, in this case practices in mental health services.

Value motivations predict burnout and intentions to leave among mental health professionals.

Background: Values guide and potentially motivate people in their lives. Aligning personal values with organisational values has the potential to improve job satisfaction, reduce burnout and lower Intentions To Leave (ITL).

Aims: To determine whether changes in Value Motivation (VM) predict burnout and ITL following training.

Updating medical school psychiatry curricula to meet projected mental health needs.

Objective: In view of the growing disease burden of mental disorders, we consider the pressing need to update medical school psychiatry education to better equip doctors to recognise and treat these conditions. Key challenges to the delivery of medical school mental health curricula, and possible directions for reform, are reviewed with the aims of stimulating collaboration and enhancing the efficiency across schools.

Conclusions: In Australia, medical school expansion provides opportunities to prepare many training doctors to meet growing mental health care needs.

A comparison of two coaching approaches to enhance implementation of a recovery-oriented service model.

Moving to recovery-oriented service provision in mental health may entail retraining existing staff, as well as training new staff. This represents a substantial burden on organisations, particularly since transfer of training into practice is often poor. Follow-up supervision and/or coaching have been found to improve the implementation and sustainment of new approaches.

Improving implementation of evidence-based practice in mental health service delivery: protocol for a cluster randomised quasi-experimental investigation of staff-focused values interventions.

Background: There is growing acceptance that optimal service provision for individuals with severe and recurrent mental illness requires a complementary focus on medical recovery (i.e., symptom management and general functioning) and personal recovery (i.

Use of a randomized multiple baseline design: rationale and design of the spirited life holistic health intervention study.

Clergy suffer from high rates of obesity, chronic disease, and depression, and simultaneously underestimate the toll these take on their daily functioning. Health interventions are needed for clergy and may be tailored to their occupational context and theological beliefs. Few studies have sought to improve clergy health.

IMPACT OF WILLIAMS LIFESKILLS TRAINING ON ANGER, ANXIETY AND AMBULATORY BLOOD PRESSURE IN ADOLESCENTS.

Background: The Williams LifeSkills (WLS) anger and stress management workshop provides training in strategies to cope with stressful situations and build supportive relationships.

Purpose: The purpose of this study was to determine the impact of school-based Williams LifeSkills training on anger, anxiety and blood pressure in adolescents.

Methods: 159 adolescents (mean age±SD=15.

Expression and characterization of Cryptococcus neoformans recombinant App1.

We characterized Cryptococcus neoformans recombinant antiphagocytic protein 1 (rApp1) by SDS-PAGE, gel filtration chromatography, circular dichroism, and fluorescence spectroscopy. rApp1 produced by C. neoformans var.

SEER coding standards result in underestimation of positive surgical margin incidence at radical prostatectomy: results of a systematic audit.

Purpose: SEER (Surveillance, Epidemiology and End Results) is the leading source of population level data on prostate cancer, including the positive surgical margin incidence at radical prostatectomy. Recently studies showed wide ranges in positive surgical margin rates among individual registries, which we hypothesized was the result of coding inaccuracies. Thus, we systematically audited SEER prostate cancer data.

Adaptation and implementation of an evidence-based behavioral medicine program in diverse global settings: The Williams LifeSkills experience.

Epidemiological research has documented the health-damaging effects of psychosocial factors like hostility, depression, anxiety, job stress, social isolation and low socioeconomic status. Several studies suggest that behavioral interventions can reduce levels of these psychosocial factors. Herein we describe the translational process whereby the Williams LifeSkills® (WLS(®)) program and products for reducing psychosocial risk factors have been developed and tested in clinical trials in the U.

Role of glucose in the expression of Cryptococcus neoformans antiphagocytic protein 1, App1.

The cryptococcus-specific protein antiphagocytic protein 1 (App1) regulates Cryptococcus neoformans virulence by controlling macrophage-driven fungal phagocytosis. This is accomplished through complement receptors (CR), specifically CR3. When inhaled, C.

Evaluation of a pharmacist-managed lipid clinic that uses point-of-care lipid testing.

Background: Hyperlipidemia is a significant, modifiable risk factor for developing coronary heart disease. Low-density lipoprotein cholesterol (LDL-C) goal achievement has improved overall, but many high-risk patients remain above the desired LDL-C goals. Published data have demonstrated the ability of pharmacist-managed lipid clinics to improve lipid management in a variety of clinical settings.

Video-based coping skills to reduce health risk and improve psychological and physical well-being in Alzheimer's disease family caregivers.

Objective: To determine whether video-based coping skills (VCS) training with telephone coaching reduces psychosocial and biological markers of distress in primary caregivers of a relative with Alzheimer's disease or related dementia (ADRD).

Methods: A controlled clinical trial was conducted with 116 ADRD caregivers who were assigned, alternately as they qualified for the study, to a Wait List control condition or the VCS training arm in which they viewed two modules/week of a version of the Williams LifeSkills Video adapted for ADRD family care contexts, did the exercises and homework for each module presented in an accompanying Workbook, and received one telephone coaching call per week for 5 weeks on each week's two modules. Questionnaire-assessed depressive symptoms, state and trait anger and anxiety, perceived stress, hostility, caregiver self-efficacy, salivary cortisol across the day and before and after a stress protocol, and blood pressure and heart rate during a stress protocol were assessed before VCS training, 7 weeks after training was completed, and at 3 months' and 6 months' follow-up.

Coping skills training to reduce psychosocial risk factors for medical disorders: a field trial evaluating effectiveness in multiple worksites.

Objective: To determine whether a commercial coping skills training program shown to reduce psychosocial risk factors in randomized clinical trials of patients with coronary heart disease is also effective in achieving similar improvements among stressed workers in a real world corporate setting.

Methods: Conduct an observational trial to evaluate the impact of the Williams LifeSkills Workshop on depression, social support, anxiety, and hostility in a sample of 110 employees working at multiple U.S.

Worldwide stress: different problems, similar solutions? Cultural adaptation and evaluation of a standardized stress management program in Hungary.

Background: Chronic stress is an important risk factor for morbidity and premature mortality at the individual and societal level.

Purpose: Our aim was to describe the process of adapting and testing the effectiveness of a structured stress management skills training program in a culture different from the one in which it was first developed.

Method: We translated an internationally used standardized behavioral intervention program into Hungarian and adapted it for use in a Hungarian cultural setting.

Interaction between gemfibrozil and warfarin: case report and review of the literature.

Possible procoagulant effects can occur when lipid-lowering fibric acid derivatives, such as gemfibrozil and fenofibrate, are taken concomitantly with warfarin. Although there are several detailed reports of fenofibrate potentiating the anticoagulant effects of warfarin, few case reports have been published regarding an interaction between gemfibrozil and warfarin. We describe a 62-year-old man who was taking warfarin for paroxysmal atrial fibrillation and came to the anticoagulation clinic for a routine follow-up.

Neurofibromatosis type 1 revisited.

Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with a worldwide incidence of approximately 1 per 2500 to 3000 individuals. Caused by a germ-line-inactivating mutation in the NF1 gene on chromosome 17, the disease is associated with increased morbidity and mortality. In the past several years, significant progress has been made in standardizing management of the major clinical features of neurofibromatosis type 1.

App1: an antiphagocytic protein that binds to complement receptors 3 and 2.

In previous studies, we showed that the pathogenic fungus Cryptococcus neoformans (Cn) produces a specific and unique protein called antiphagocytic protein 1 (App1), which inhibits phagocytosis of Cn by alveolar macrophages (AMs). Phagocytosis of Cn by AMs occurs mainly through a complement- or Ab-mediated mechanism. Among AM receptors, complement receptor 3 (CR3) and FcRgamma are the most common receptors involved in the phagocytic process.