Publications by authors named "Virginia Speck"
Cytoskeleton (Hoboken)
May 2020
Article Synopsis
- Microtubule-associated proteins play a crucial role in regulating the behavior of microtubules during various cellular activities, particularly through the action of microtubule severing enzymes.
- These enzymes destabilize microtubules by removing tubulin subunits, with a proposed mechanism involving the unfolding of tubulin dimers via forces applied to their carboxy-terminal tails.
- Molecular simulations were conducted to explore this mechanism, revealing that the most accurate model of severing involves a cooperative removal of segments from the microtubule structure, influenced by the concentration and positioning of severing enzymes.
