Publications by authors named "Virginia Sinigiani"
The nucleocapsid protein Np of SARS-CoV-2 is involved in the replication, transcription, and packaging of the viral genome, but it also plays a role in the modulation of the host cell innate immunity and inflammation response. Ectopic expression of Np alone was able to induce significant changes in the proteome of human cells. The cellular RNA helicase DDX1 was among the proteins whose levels were increased by Np expression.
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- DDX3X is an RNA helicase linked to viral replication and cancer progression, and new inhibitors have been developed to block its activity.
- These inhibitors effectively decreased cell proliferation across various cancer types, including those with low DDX3X expression.
- The compound BA103 showed significant promise in glioblastoma models by reducing tumor growth and migration, while also targeting the oncogenic protein β-catenin, with minimal side effects.
Tuberculosis (TB) is one of the major causes of death related to antimicrobial resistance worldwide because of the spread of multi- and extensively drug resistant (multi-drug resistant (MDR) and extensively drug-resistant (XDR), respectively) clinical isolates. To fight MDR and XDR tuberculosis, three new antitubercular drugs, bedaquiline (BDQ), delamanid, and pretomanid were approved for use in clinical setting. Unfortunately, BDQ quickly acquired two main mechanisms of resistance, consisting in mutations in either gene, encoding the target, or in , coding for the repressor of the MmpS5-MmpL5 efflux pump.
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