Publications by authors named "Virginia Reddy"
Article Synopsis
- Janus kinase inhibitors (JAKi) have been used since 2012 for rheumatoid arthritis (RA) patients who don't respond to traditional treatments, showing similar effectiveness and safety to biologics.
- A recent clinical trial found that tofacitinib, one type of JAKi, had a higher incidence of major cardiovascular events and malignancy compared to TNF inhibitors, leading to safety concerns.
- As a result, the FDA and EMA have restricted JAKi use to RA patients who have already tried and not succeeded with TNF inhibitors due to increased risks.
Article Synopsis
- Recent articles review the use of Janus Kinase inhibitors (Jaki) for treating rheumatoid arthritis (RA) in patients who have not responded to conventional treatments (csDMARDs).
- EULAR and ACR have updated guidelines recommending Jaki use after csDMARD failure, highlighting their efficacy as monotherapy versus combination therapy.
- Jaki are becoming a common alternative to biologics, though there are concerns about increased risks of venous thromboembolism (VTE) and conflicting data on this risk, with ongoing research into strategies for optimizing treatment.
Purpose Of The Review: Three Janus kinase (JAK) inhibitors are approved for rheumatoid arthritis (RA) with a fourth awaiting approval. Multiple clinical trial results with these molecules have recently been reported. These were the first small molecule oral targeted synthetic DMARDs (tsDMARDs) to be approved for RA.
View Article and Find Full Text PDFObjective: Research has examined the association of folate-dependent gene polymorphisms with methotrexate (MTX) toxicity in racially homogenous patients with rheumatoid arthritis (RA). We examined the influence of MTX transporter gene polymorphisms on MTX toxicity in 2 racial groups of patients with RA.
Methods: Using a retrospective cross-validation approach, the association of polymorphisms in 6 genes in the MTX cellular pathway with MTX toxicity was examined in training and validation cohorts.