Triclosan blocks MMP-13 expression in hormone-stimulated osteoblasts.

Background: Matrix metalloproteinase-13 (MMP-13) is an important enzyme for the modulation of bone turnover and gingival recession. Elevated levels of MMP-13 are associated with alveolar bone resorption, periodontal ligament breakdown, and gingival attachment loss, which are the clinical symptoms of periodontal disease. Evidence continues to suggest that periodontal disease contributes to oral tissue breakdown and is linked to numerous systemic conditions.

Label-free quantitative proteomics reveals differentially regulated proteins in experimental gingivitis.

We investigated the sequential protein expression in gingival crevicular fluid samples during the induction (I) and resolution (R) of experimental gingivitis. Periodontally and systemically healthy volunteers (n = 20) participated in a three-week experimental gingivitis protocol, followed by debridement and two weeks of regular plaque control. Gingival crevicular fluid (GCF) samples were collected at baseline, Day 7, 14, and 21 (induction; I-phase), and at Day 21, 25, 30, and 35 (resolution; R-phase).

Comparison of the short-term antiplaque/antibacterial efficacy of two commercial dentifrices.

Objective: The objective of these three clinical trials was to compare the impact of two commercial products, Colgate Total and Crest Pro-Health, on the formation of dental plaque over a 24-hour period of time. The studies utilized the Modified Gingival Margin Plaque Index (MGMPI), a validated and reliable clinical method for assessing the efficacy of products in reducing plaque build-up.

Methods: Colgate Total and Crest Pro-Health were the test products for all three clinical trials.

Evaluation of the antiplaque efficacy of two cetylpyridinium chloride-containing mouthwashes.

Objective: The purpose of this clinical study was to evaluate the efficacy in reducing dental plaque regrowth of two mouthwashes containing 0.075% cetylpyridinium chloride (CPC), one with 6% alcohol and one alcohol-free, as compared to a negative control mouthwash without CPC, using the Modified Gingival Margin Plaque Index (MGMPI).

Methods: The study was a double-blind, randomized, three-way crossover, controlled design.

The use of the Modified Gingival Margin Plaque Index (MGMPI) method to investigate the inhibitory effect of various toothpastes on dental plaque formation.

Objective: Colgate Total (CTT) is the only FDA-approved toothpaste for antiplaque and antigingivitis benefits. The objective of this study was to compare the impact of Colgate Total Pharma (CTP), a new variant of Colgate Total, with Colgate Regular Toothpaste (CRT) on plaque formation over a 24-hour period following a single use of the dentifrice.

Methods: CTP and CRT were the two test products.

Analysis of the antibacterial activity and plaque control benefit of colgate total dentifrice via clinical evaluation and real-time polymerase chain reaction.

Objective: This study analyzed, from a combined clinical and molecular biologic perspective, the antibacterial and antiplaque efficacy of Colgate Total dentifrice (CTD).

Methodology: A single-blind crossover study design utilized 11 healthy human subjects. After a one-week washout period, subjects donated dental plaque, received a dental prophylaxis, and subsequently brushed with a test product.

Comparison of two clinical methods for evaluating the anti-plaque efficacy of a dentifrice.

Objective: The objective of this research was to assess two different published methods of plaque level evaluation on human subjects, and to determine whether both methods can produce similar findings to the point that the methods can be used interchangeably.

Methodology: Healthy human volunteers entered into a number of double-blind, cross-over clinical trials. Two plaque scoring methods were used: The Modified Gingival Margin Plaque Index (MGMPI) and the Turesky Modified Quigley-Hein (TMQH).

Effectiveness of a triclosan/copolymer dentifrice on microbiological and inflammatory parameters.

According to the US Surgeon General's report, "Oral Health in America," published in 2000, most adults in the United States show some degree of periodontal pathology, with severe periodontal diseases affecting about 14% of middle-aged adults. Periodontal diseases are polymicrobial-induced inflammatory diseases, and they vary from mild gingival inflammation to severe deterioration of the periodontium, ie, loss of periodontal supportive tissues and, ultimately, tooth loss. New evidence shows that periodontal diseases may impact systemic health.

The development of a new dental probe and a new plaque index.

Objective: A curved periodontal probe has been developed to measure the length of newly formed plaque along the gingival margin of a tooth and the length of the entire gingival margin of the tooth. Plaque is expressed as a percent of the tooth's gingival margin, and is defined as the Modified Gingival Margin Plaque Index (MGMPI). The purpose of this research was to evaluate the efficacy of three marketed antiplaque products using the MGMPI.

Safety profile of a new liquid whitening gel.

Colgate Simply White Clear Whitening Gel, an at-home tooth-whitening product purchased over the counter, contains 18% carbamide peroxide (equivalent to 6.5% hydrogen peroxide) as the active ingredient in a brush-applied liquid gel. The excipients include ingredients commonly used in dentifrices.