Publications by authors named "Virginia F Byron"
Purpose: Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer that commonly harbors HER2 gene amplification. We investigated the effectiveness of HER2 inhibition using lapatinib and trastuzumab in vitro and in xenografts derived from USC cell lines and USC patient-derived xenografts.
Experimental Design: Immunohistochemistry and FISH were performed to assess HER2 expression in 42 primary USC specimens.
Objective: Uterine serous carcinoma (USC) represents an aggressive subtype of endometrial cancer. We sought to understand Notch pathway activity in USC and determine if pathway inhibition has anti-tumor activity.
Methods: Patient USC tissue blocks were obtained and used to correlate clinical outcomes with Notch1 expression.