Publications by authors named "Virginia Di Natale"
Background: Patients with high-risk (HR) prostate cancer (PCa) represent a heterogeneous group, however, current treatment guidelines do not consider their specific features. The objective of this study was to evaluate treatment trends and outcomes in HR patients defined by PSA alone and otherwise low-risk features.
Methods: Using the National Cancer Database, we identified patients diagnosed with HR PCa between 2010 and 2016.
Background: Mucosal melanoma involving the urethra is a rare disease with distinct clinical and molecular characteristics and poor outcomes. Our current knowledge is limited by the small number of reports regarding this disease.
Objective: To describe the clinical, pathological, and molecular characteristics of urethral melanoma.
Purpose: Transrectal ultrasound (US) imaging is paramount to the successful completion of prostate biopsies. Certain US features have been associated with prostate cancer (PCa), but their utility remains controversial. We explored the role of multiparametric US (mpUS) in the detection of clinically significant PCa.
View Article and Find Full Text PDFObjective: To assess the national case logs of the first graduating urologic resident cohorts to have trained during the COVID-19 pandemic for effects on surgical volumes.
Methods: The nationally aggregated Accreditation Council for Graduate Medical Education urology resident case logs were obtained for graduates of academic years (AYs) 2015-2016 through 2020-2021. Case volume differences for tracked index categories were compared between AYs with a 1-way analysis of variance.
Article Synopsis
- Metastatic progression is the leading cause of death in cancer patients, yet the specific genomic mechanisms behind it are not well understood.
- Researchers analyzed data from over 25,000 cancer patients in the MSK-MET cohort, discovering connections between genomic changes and how various tumors spread in 50 different cancer types.
- The study revealed that chromosomal instability is linked to metastatic spread in certain cancers (like prostate and lung adenocarcinomas) but not others (like colorectal cancer), providing insights into how these genomic alterations affect cancer progression and spread to specific organs.
Background: Elevated preoperative hemoglobin A1c (HbA1c) is a predictor of poor outcomes following coronary artery bypass grafting (CABG), but the role of increased postoperative glucose variability (GV) is unknown. We hypothesized that short-term postoperative GV is associated with an increased risk of postoperative atrial fibrillation following isolated CABG.
Methods: Multicenter retrospective study of 2073 patients who underwent isolated CABG from January 2012 to March 2018.