Clinical and laboratory results in vaginal wall restoration using a fractional-pixel-CO laser: histological findings and changes in the Ki67 protein and telomere length.

Thermal deposition of laser energy in the vaginal epithelium in genitourinary syndrome of menopause (GSM) results in clinical and biological effects, but many cellular and molecular changes indicating cell proliferation or senescence inhibition are unknown. The aim of this study is to evaluate the clinical efficacy of the fractional-pixel-CO laser in the possible improvement of GMS signs and symptoms that can be correlated with histological changes or with cellular or molecular indicators of restoration. A detailed prospective study was designed to assess 17 women diagnosed with GSM who were treated intravaginally with two laser sessions.

Procedure and results on lower face and neck rejuvenation using a temperature-controlled bipolar fractional radiofrequency microneedling device.

Background And Objective: Radiofrequency (RF) devices which are under ongoing technological development, are being increasingly used for minimally invasive rejuvenation procedures. The objective is to evaluate the efficacy and safety of a procedure that uses bipolar RF microneedles for rejuvenation of the lower face and neck.

Study Design And Methods: A prospective clinical and histological study, with a blind evaluation of the results by independent evaluators.