Publications by authors named "Virginia Anastassova"
Biochem Pharmacol
February 2012
Article Synopsis
- To infect human cells, HIV binds to the CD4 receptor and either CXCR4 or CCR5; AMD11070 is the first oral small molecule that targets CXCR4 in this context.
- AMD11070 effectively inhibits various interactions related to CXCR4, including SDF-1α binding and SDF-1 induced cellular responses, showing its potency through several assays with low IC50 values.
- The compound is selective for CXCR4, meaning it does not affect other receptors like CXCR3 or CCR5, and operates as an allosteric inhibitor, suggesting it alters receptor function rather than blocking it outright.
