Publications by authors named "Vipul Kumar Patel"
There is an urgent need to identify biomarkers of early response that can accurately predict the benefit of immune checkpoint inhibitors (ICI). Patients receiving durvalumab/tremelimumab had tumor samples sequenced before treatment (baseline) to identify variants for the design of a personalized circulating tumor (ctDNA) assay. ctDNA was assessed at baseline and at 4 and/or 8 weeks into treatment.
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- The study used diffusion tensor imaging (DTI) to examine brain structures in 36 mild traumatic brain injury (mTBI) patients compared to 37 orthopedic injury participants, aiming to identify recovery patterns.
- While no significant differences in brain structure among groups were found at baseline or follow-up, the orthopedic group showed increased global mean diffusivity in gray and white matter over time.
- DTI revealed elevated radial diffusivity in the corona radiata for mTBI at baseline, suggesting potential injury-related edema, though changes were not significant when looking at mTBI patients over time.