Lycopene as a Potential Anti-inflammatory Therapeutic Agent for Temporomandibular Joint Disorders: A Narrative Review.

Temporomandibular joint disorder is a common condition characterized by jaw joint and muscle pain and its treatment is often multifaceted. While conventional treatment modalities exist for the same, interest has grown in exploring alternative therapies such as antioxidants for their potential analgesic properties. The prospective therapeutic use of lycopene, a naturally occurring antioxidant present in tomatoes and other fruits, as an anti-inflammatory therapeutic modality in the management of temporomandibular joint problems is examined in this narrative review.

Photoredox Hydroxy-arylation of the Terminal Double Bond of -Substituted 3-Methyleneisoindolin-1-ones in Visible Light.

Mild and efficient ruthenium-catalyzed hydroxy-arylation of the terminal double bond of -substituted 3-methyleneisoindolin-1-ones is described. The reaction takes place with aryl diazonium salt as the arylating reagent and water as the hydroxyl source in visible light at ambient temperature. The strategy entails vicinal difunctionalization of alkene and enables construction of 3-benzyl-3-hydroxyisoindolin-1-one heterocyclic scaffolds in moderate to good yields.

Phytomedicines explored under and studies against coronavirus: An opportunity to develop traditional medicines.

The widespread COVID-19 pandemic, caused by novel coronavirus SARS-CoV-2, has emanated as one of the most life-threatening transmissible diseases. Currently, the repurposed drugs such as remdesivir, azithromycine, chloroquine, and hydroxychloroquine are being employed in the management of COVID-19 but their adverse effects are a matter of concern. In this regard, alternative treatment options , traditional medicine, medicinal plants, and their phytochemicals, which exhibit significant therapeutic efficacy and show a low toxicity profile, are being explored.

Ramping of pH Across the Water-Pool of a Reverse Micelle.

In this work, we have addressed the problem of "acidity" of the water-pool of a reverse micelle (RM) through the well-known inversion of sucrose reaction as a tool of investigation. This reaction has been performed inside positively and negatively charged RM and the rates are compared with that in bulk water. We propose that the buffer-like action in a water-pool is much stronger than expected earlier.

Divergent synthesis of various iminocyclitols from D-ribose.

A very efficient route to the diastereoselective synthesis of polyhydroxy pyrrolidines, piperidines and azepanes from an aldehyde derivative of ribose is reported. Asymmetric α-amination of aldehydes using proline catalysed hydrazination is the key step in the synthesis. The method utilizes the stereocenters present in ribose and the extra carbon atoms present in the target molecules are incorporated using Wittig reactions.

Fabrication of artificially stacked ultrathin ZnS/MgF2 multilayer dielectric optical filters.

We report a design and fabrication strategy for creating an artificially stacked multilayered optical filters using a thermal evaporation technique. We have selectively chosen a zinc sulphide (ZnS) lattice for the high refractive index (n = 2.35) layer and a magnesium fluoride (MgF2) lattice as the low refractive index (n = 1.