Hydroxyapatite-bioglass nanocomposites: Structural, mechanical, and biological aspects.

This research work focuses on the fabrication and study of a series of nanocomposites consisting of two types of hydroxyapatite (HA), obtained by precipitate (HAP) and sol-gel (HAG) methods, and a boro-silico-phosphate bioglass. The microstructure and chemical, mechanical, and biological properties as functions of three factors, namely (i) the type of hydroxyapatite, (ii) glass content, and (iii) sintering temperature, were investigated. It was found that all of these factors affect the final composition and microstructure, especially, porosity, which shows significantly lower values for HAP-based composites than for HAG-based ones and higher values for higher glass content.

A Pilot Animal Study Aimed at Assessing the Mechanical Quality of Regenerated Alveolar Bone.

Purpose: Bone regeneration procedures are often evaluated based on biologic aspects only. As regenerated bone also has to ensure primary implant stability, the goal of this study was to determine the mechanical quality of regenerated bone.

Materials And Methods: Six adult minipigs were allocated for this experiment with four mandibular study sites each established following tooth removal.

Mesenchymal stem cells proliferation and remote manipulation upon exposure to magnetic semiconductor nanoparticles.

In this paper, we report on spatial redistribution of bone marrow mesenchymal stem cells loaded with magnetic nanoparticles under the influence of continuously applied magnetic field. Semiconductor nanoparticles were synthesized by epitaxial growth of a GaN thin layer on magnetic sacrificial core consisting of ZnFeO nanoparticles. Different quantities of nanoparticles were incubated with mesenchymal stem cells.

Effect of intraoperative bone quality testing on bone healing and osseointegration of dental implants.

Purpose: A novel diagnostic device (BoneProbe) for evaluating alveolar bone quality during dental implant surgery has recently been developed. The underlying measurement principle is based on a compressive test of bone, which may subsequently affect bone healing and osseointegration of dental implants.

Materials And Methods: Six implant sites each were created in the rear left tibia of four sheep and used for bone quality testing with the BoneProbe, while empty osteotomies and implants placed without testing served as controls.

Vertical osteoconductive characteristics of titanium implants with calcium-phosphate-coated surfaces - a pilot study in rabbits.

Introduction: Osteoconductive characteristics of different implant surface coatings are in the focus of current interest. The aim of the present study was to compare the vertical osteoconductivity at the implant shoulder of supracrestal inserted calcium-phosphate coated implants (SLA-CaP) with conventional sand-blasted/acid-etched (SLA) implants in a rabbit model.

Materials And Methods: SLA-CaP and SLA implants were inserted bilaterally in the mandible of four rabbits in a split-mouth design.

PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts.

Missense mutations that reduce or abrogate myeloid cell expression of the F-BAR domain protein, proline serine threonine phosphatase-interacting protein 2 (PSTPIP2), lead to autoinflammatory disease involving extramedullary hematopoiesis, skin and bone lesions. However, little is known about how PSTPIP2 regulates osteoclast development. Here we examined how PSTPIP2 deficiency causes osteopenia and bone lesions, using the mouse PSTPIP2 mutations, cmo, which fails to express PSTPIP2 and Lupo, in which PSTPIP2 is dysfunctional.